Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease



Davidson, Isobel and Robinson, S D and Harding, S A and Cummins, P and Din, J N and Sarma , J and Fox , K A A and Boon , N A and Newby , D E (2006) Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease. Platelets, 17 (3). pp. 158-162. ISSN 0953-7104

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Abstract

Platelet-monocyte binding and surface P-selectin expression are sensitive markers of platelet activation. Endothelium-derived factors are known to inhibit platelet activation and may confer important anti-atherothrombotic effects. We assessed the relationship between platelet activation and endothelium-dependent vasomotion in patients with coronary heart disease (CHD). Twenty male patients with stable CHD were compared with 20 healthy men. Platelet-monocyte binding and platelet surface expression of P-selectin were assessed using two-colour flow cytometry on whole blood. Forearm blood flow was assessed in patients using venous occlusion plethysmography during intra-arterial infusions of substance P, acetylcholine and sodium nitroprusside. Platelet activation was higher in patients than healthy men (platelet-monocyte binding, 27 ± 3 vs. 20 ± 1%; P < 0.05). In patients with CHD, there was an inverse correlation between maximal substance P induced vasodilatation and both platelet-monocyte binding (P = 0.003) and P-selectin expression (P = 0.02). A similar correlation was observed between platelet-monocyte binding and the vasomotor response to acetylcholine (P = 0.08) but not with sodium nitroprusside. In patients with stable coronary heart disease, there is a strong inverse relationship between markers of platelet activation and endothelium-dependent vasomotor function. This may explain the pathophysiological mechanism linking endothelial vasomotor dysfunction and the risk of acute atherothrombotic events.

Item Type: Article
Uncontrolled Keywords: Atherosclerosis; coronary disease; endothelial function; forearm blood flow; platelets
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 09 Jun 2008 11:37
Last Modified: 19 Sep 2012 10:56
URI: http://eresearch.qmu.ac.uk/id/eprint/104

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