Hindawi, R and Al-Dujaili, Emad A S and Padfield, P (1985) The role of prostaglandins in aldosterone and corticosterone secretion by isolated perfused rat zona glomerulosa cells. Prostaglandins, Leukotrienes and Medicine, 20 (2). pp. 121-128. ISSN 02621746
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Official URL: http://dx.doi.org/10.1016/0262-1746(85)90002-2
The effect of PGE2 and PGA1 on aldosterone and corticosterone biosynthesis by isolated perfused rat zona glomerulosa cells has been studied. Incremental doses of each of the. prostaglandins tested produced a progressive rise in aldosterone (3–4 fold increase for PGE2 and 2–3 fold increase for PGA1) and corticosterone (4–8 fold for PGE2 and 2–4 fold for PGA1). The cyclo-oxygenase inhibitors indomethacin and meclofenamate however produced no effect on basal steroidogenesis. PGE2 produced a marked potentiation of angiotensin II-induced aldosterone secretion (45.7 ± 13.6 to 144.3 ± 19.4 pg/ml with angiotensin II alone and 78.4 ± 16.6 to 269.9 ± 39.5 pg/ml with angiotensin II + PGE2), In contrast, there was no effect of PGE2 on ACTH or serotonin-induced aldosterone secretion. These data show that PGE2 and PGA1 can directly stimulate rat adrenal steroidogenesis and suggest that PGE2 may play a role in mediating angiotensin II-induced aldosterone secretion by rat zona glomerulosa cells
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