Development and application of a direct radioimmunoassay for aldosterone in saliva



Atherden, S and Corrie, J and Jones, D and Al-Dujaili, Emad A S and Edwards, C (1985) Development and application of a direct radioimmunoassay for aldosterone in saliva. Steroids, 46 (4-5). pp. 845-855. ISSN 0039128X

Full text not available from this repository.

Abstract

A previously described direct radioimmunoassay for plasma aldosterone has been modified to enable direct measurement of the steroid in saliva. The specificity of the method has been demonstrated by assay after high pressure liquid chromatographic purification of saliva extracts. Assay of matched plasma and saliva samples taken from normal subjects during unrestricted and controlled sodium intakes, either under basal conditions or while undergoing ACTH stimulation or dexamethasone suppression, confirms that salivary aldosterone values provide a good reflection of levels in plasma. Mean salivary aldosterone values are approximately one-third of those in plasma. Sampling immediately upon waking appears to provide reliable values for salivary aldosterone, and the potential application of this technique to the screening of hypertensive patients is discussed.

Item Type: Article
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 03 Feb 2010 13:14
Last Modified: 26 Nov 2012 14:51
URI: http://eresearch.qmu.ac.uk/id/eprint/1178

Actions (login required)

View Item View Item