Al-Dujaili, Emad A S and Williams, B and Edwards, C and Salacinski, P and Lowry, P (1982) Human gamma-melantrophin precursor potentiates corticotrophin-induced adrenal steroidogenesis by stimulating messenger RNA synthesis. Biochemical Journal, 204 . pp. 301-305. ISSN 0264-6021
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Official URL: http://www.biochemj.org/bj/204/bj2040301.htm
Circulating human gamma-melanotropin precursor (76 amino acids) [N-POC(1-76) enhances the corticosterone and aldosterone response to corticotropin by isolated perfused rat adrenal cells [Al-Dujaili, Hope, Estivariz, Lowry & Edwards (1981) Nature (London) 291, 156-159]. Actinomycin D (4 x 10(-6) mol/litre) did not significantly affect corticotropin-induced corticosterone or aldosterone outputs, but completely inhibited the potentiating action of gamma-melanotropin precursor on rat adrenal cells. This suggests that the precursor enhances corticotropin-induced steroidogenesis via an increase in available mRNA produced from DNA transcription.
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