Human gamma-melantrophin precursor potentiates corticotrophin-induced adrenal steroidogenesis by stimulating messenger RNA synthesis



Al-Dujaili, Emad A S and Williams, B and Edwards, C and Salacinski, P and Lowry, P (1982) Human gamma-melantrophin precursor potentiates corticotrophin-induced adrenal steroidogenesis by stimulating messenger RNA synthesis. Biochemical Journal, 204. pp. 301-305. ISSN 0264-6021

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Abstract

Circulating human gamma-melanotropin precursor (76 amino acids) [N-POC(1-76) enhances the corticosterone and aldosterone response to corticotropin by isolated perfused rat adrenal cells [Al-Dujaili, Hope, Estivariz, Lowry & Edwards (1981) Nature (London) 291, 156-159]. Actinomycin D (4 x 10(-6) mol/litre) did not significantly affect corticotropin-induced corticosterone or aldosterone outputs, but completely inhibited the potentiating action of gamma-melanotropin precursor on rat adrenal cells. This suggests that the precursor enhances corticotropin-induced steroidogenesis via an increase in available mRNA produced from DNA transcription.

Item Type: Article
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 04 Feb 2010 16:03
Last Modified: 19 Mar 2014 12:56
URI: http://eresearch.qmu.ac.uk/id/eprint/1187

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