Investigating the inhibitory activity of green coffee and cacao bean extracts on pancreatic lipase



Almoosawi, Suzana and McDougall, G J and Fyfe, Lorna and Al-Dujaili, Emad A S (2010) Investigating the inhibitory activity of green coffee and cacao bean extracts on pancreatic lipase. Nutrition Bulletin, 35 (3). pp. 207-212. ISSN 1471-9827

[img] PDF
eResearch_1832.pdf
Restricted to Repository staff only

Download (219kB) | Request a copy

Abstract

The present study investigated the effects of green coffee bean extract and Theobroma cacao bean extract on pancreatic lipase activity in vitro. Green coffee bean extract produced a J-shaped dose-dependent inhibition of pancreatic lipase with the percentage inhibition of pancreatic lipase ranging from 11.8% to 61.5%. Similar concentrations of Theobroma cacao failed to produce any effect on pancreatic lipase. Non-linear regression analysis revealed that the concentration of green coffee bean extract required to elicit a 50% inhibition of pancreatic lipase activity (IC50) was approximately 43 μM. In conclusion, extracts of green coffee beans but not Theobroma cacao possess potent inhibitory activity against pancreatic lipase. © 2010 The Authors. Journal compilation © 2010 British Nutrition Foundation.

Item Type: Article
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 12 Oct 2010 11:06
Last Modified: 19 Mar 2014 12:58
URI: http://eresearch.qmu.ac.uk/id/eprint/1832

Actions (login required)

View Item View Item