Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice

Beglopoulos, V. and Tulloch, J. and Roe, A. D. and Daumas, S. and Ferrington, Linda and Watson, R. and Fan, Z. and Hyman, B. T. and Kelly, P. A. T. and Bard, F. and Morris, R. G. M. (2016) Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice. Nature Communications, 7. p. 11761. ISSN 2041-1723

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Official URL: http://doi.org/10.1038/ncomms11761

Abstract

Earlier diagnosis and treatment of Alzheimer’s disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent animal model of aspects of the disease, we here show using clinically relevant methodologies that very young, pre-pathological PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryptic deficits that are normally undetected using standard methods of assessment. Despite learning a spatial memory task normally and displaying normal brain glucose uptake, they display faster forgetting after a long delay following performance to a criterion, together with a strong impairment of brain glucose uptake at the time of attempted memory retrieval. Preliminary observations suggest that these deficits, likely caused by an impairment in systems consolidation, could be rescued by immunotherapy with an anti-β-amyloid antibody. Our data suggest a biomarker strategy for the early detection of β-amyloid-related abnormalities.

Item Type: Article
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 08 Jun 2016 09:27
Last Modified: 02 Feb 2017 15:44
URI: http://eresearch.qmu.ac.uk/id/eprint/4362

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