A Randomised Double Blind Placebo Controlled Trial of a Nucleotide-Containing Supplement Nucell® on Symptoms of Participants with the Common Cold - A Pilot Study®

Davidson, Isobel and Fyfe, Lorna (2016) A Randomised Double Blind Placebo Controlled Trial of a Nucleotide-Containing Supplement Nucell® on Symptoms of Participants with the Common Cold - A Pilot Study®. EC Nutrition.

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Abstract

Objectives: To ascertain whether a nucleotide containing nutritional supplement Nucell® attenuates self-reported symptoms of the common cold. Design: A randomised controlled trial. Setting: A University. Participants: Participants with self-reported symptoms of the common cold but otherwise healthy individuals. Intervention: Nucell® capsules containing a yeast-based nucleotide preparation or placebo were provided over a 28 day period. Outcome Measures: Subjective ratings of symptoms were recorded by self-administered questionnaires using a nine-point scale. Salivary IgA concentrations were analysed from samples collected during the first 7 days and then at days 14,21 and 28 of supplementation. Total and white blood cell counts were also measured throughout the intervention. Results: Thirty-six participants completed the study. Nineteen received Nucell® and 17 received the placebo. The mean age of participants was similar (29.8 + 2.5 in Nucell group v 30.7 + 2.7 in control group) and the time participants had been suffering from cold-related symptoms was not significantly different in each treatment group (2.5 + 0.40 days in Nucell® v 2.9 + 0.47 days in control group). Severity of self-reported symptoms was significantly attenuated in the Nucell® treated group in the first week of supplementation for questions asked with respect to taste, painful sinuses and earache (p< 0.05). Supplementation with Nucell® did not adversely affect total or differential white blood counts. Conclusion: These results suggest that Nucell® supplementation administered as a treatment for cold-related symptoms may reduce the severity of specific symptoms particularly in the early infective phase. In conclusion, Nucell® supplementation may provide subjective relief of some cold-related symptoms and may be of significant benefit administered as a treatment in participants where sinus pain, earache and diminished taste are common symptoms.

Item Type: Article
Divisions: School of Health Sciences > Dietetics, Nutrition and Biological Sciences
Date Deposited: 15 Jun 2016 10:43
Last Modified: 02 Feb 2017 15:44
URI: http://eresearch.qmu.ac.uk/id/eprint/4363

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