Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training



Sakkas, G K and Sargeant, A J and Mercer, Tom and Ball, Derek and Koufaki, Pelagia and Karatzaferi, C and Naish, P F (2003) Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training. Nephrology Dialysis Transplantation, 18 (9). pp. 1854-1861. ISSN 09310509

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Abstract

Background. In the present study we investigated the effect of a 6-month aerobic exercise programme on the morphology of the gastrocnemius muscle of end-stage renal disease (ESRD) patients. Methods. Twenty-four ESRD patients volunteered to participate in the training programme and underwent muscle biopsy before training. Eighteen patients completed the training programme of whom nine agreed to a post-training biopsy (one woman and eight men, mean age 56 ± 15 years). Data are presented for the nine subjects who were biopsied before (PRE) and after training (POST) and separately for the 15 subjects for whom we only have a biopsy before training (cross-sectional group). Results. There were no significant differences (P > 0.05) in fibre type distribution or myosin heavy chain (MyHC) expression between the cross-sectional and PRE/POST groups. The mean cross-section fibre area after training (POST) increased by 46% compared with the PRE training status (P < 0.01). The proportion of atrophic fibres decreased significantly after training in type I, IIa and IIx fibre populations (from 51 to 15%, 58 to 21% and 62 to 32%, respectively). Significant differences were also found in capillary contact per fibre (CC/F), with the muscle having 24% (P < 0.05) more CC/F compared with the PRE training status. No significant differences in cytochrome c oxidase concentration were found between the groups. Conclusions. In conclusion, exercise appeared to be beneficial in renal rehabilitation by correcting the fibre atrophy, increasing the cross-section fibre area and improving the capillarization in the skeletal muscle of renal failure patients.

Item Type: Article
Additional Information: Research publication emanating from 2 related (and externally funded) PhD studies (Sakkas; with Sargeant as Director of Studies and Mercer as Supervisor; Koufaki with Mercer as Director of Studies) and activities of Renal Rehabilitation research group led by Mercer and Naish
Uncontrolled Keywords: CAPD; capillary density; cytochrome c oxidase; exercise training; fibre types; gastrocnemius; haemodialysis
Divisions: School of Health Sciences > Physiotherapy
Date Deposited: 22 May 2008 13:07
Last Modified: 19 Mar 2014 12:54
URI: http://eresearch.qmu.ac.uk/id/eprint/95

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