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dc.rights.licenseCreative Commons Attribution 4.0 Unported (CC BY 4.0) license
dc.contributor.authorStagg, Helen R.en
dc.contributor.authorAbubakar, Ibrahimen
dc.contributor.authorCampbell, Colin N. J.en
dc.contributor.authorCopas, Andrewen
dc.contributor.authorDarvell, Marciaen
dc.contributor.authorHorne, Roberten
dc.contributor.authorKielmann, Karinaen
dc.contributor.authorKunst, Heinkeen
dc.contributor.authorMandelbaum, Mikeen
dc.contributor.authorPickett, Elishaen
dc.contributor.authorStory, Alistairen
dc.contributor.authorVidal, Nicole L.en
dc.contributor.authorWurie, Fatimaen
dc.contributor.authorLipman, Marcen
dc.date.accessioned2019-10-17T12:53:56Z
dc.date.available2019-10-17T12:53:56Z
dc.date.issued2019-12-17
dc.identifier.citationStagg, H. R., Abubakar, I., Campbell, C. N. J., Copas, A., Darvell, M., Horne, R., Kielmann, K., Kunst, H., Mandelbaum, M., Pickett, E., Story, A., Vidal, N. L., Wurie, F. & Lipman, M. (2019) IMPACT study on intervening with a manualised package to achieve treatment adherence in people with tuberculosis: Protocol paper for a mixed-methods study, including a pilot randomised controlled trial. BMJ Open, 9(12).en
dc.identifier.issn2044-6055en
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/10112
dc.identifier.urihttps://doi.org/10.1136/bmjopen-2019-032760
dc.identifier.urihttp://bmjopen.bmj.com/cgi/content/full/bmjopen-2019-032760
dc.descriptionKielmann, Karina - ORCID 0000-0001-5519-1658 https://orcid.org/0000-0001-5519-1658en
dc.description.abstractIntroduction Compared with the rest of the UK and Western Europe, England has high rates of the infectious disease tuberculosis (TB). TB is curable, although treatment is for at least 6 months and longer when disease is drug resistant. If patients miss too many doses (non-adherence), they may transmit infection for longer and the infecting bacteria may develop resistance to the standard drugs used for treatment. Non-adherence may therefore risk both their health and that of others. Within England, certain population groups are thought to be at higher risk of non-adherence, but the factors contributing to this have been insufficiently determined, as have the best interventions to promote adherence. The objective of this study was to develop a manualised package of interventions for use as part of routine care within National Health Services to address the social and cultural factors that lead to poor adherence to treatment for TB disease.
dc.description.abstractMethods and analysis This study uses a mixed-methods approach, with six study components. These are (1) scoping reviews of the literature; (2) qualitative research with patients, carers and healthcare professionals; (3) development of the intervention; (4) a pilot randomised controlled trial of the manualised intervention; (5) a process evaluation to examine clinical utility; and (6) a cost analysis.
dc.description.abstractEthics and dissemination This study received ethics approval on 24 December 2018 from Camberwell St. Giles Ethics Committee, UK (REC reference 18/LO/1818). Findings will be published and disseminated through peer-reviewed publications and conference presentations, published in an end of study report to our funder (the National Institute for Health Research, UK) and presented to key stakeholders.
dc.description.abstractTrial registration number ISRCTN95243114
dc.description.abstractSecondary identifying numbers University College London/University College London Hospitals Joint Research Office 17/0726. National Institute for Health Research, UK 16/88/06.
dc.description.urihttps://doi.org/10.1136/bmjopen-2019-032760en
dc.description.urihttp://bmjopen.bmj.com/cgi/content/full/bmjopen-2019-032760
dc.language.isoenen
dc.publisherBMJen
dc.relation.ispartofBMJ Openen
dc.rights© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTuberculosisen
dc.subjectMedication Adherenceen
dc.subjectManualsen
dc.subjectProtocolen
dc.subjectPilot Studiesen
dc.titleIMPACT study on intervening with a manualised package to achieve treatment adherence in people with tuberculosis: Protocol paper for a mixed-methods study, including a pilot randomised controlled trialen
dc.typeArticleen
dcterms.accessRightspublic
dcterms.dateAccepted2019-10-11
dc.date.updated2020-01-10
dc.description.volume9
dc.description.ispublishedpub
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2019-12-17
refterms.dateFCD2020-01-10
refterms.depositExceptionpublishedGoldOAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorKielmann, Karinaen
qmu.authorVidal, Nicole L.en
qmu.centreInstitute for Global Health and Developmenten
dc.description.statuspub
dc.description.number12
refterms.versionVoRen
refterms.dateDeposit2020-01-10


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Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 Unported (CC BY 4.0) license