Queen Margaret University logo
    • Login
    View Item 
    •   QMU Repositories
    • eResearch
    • School of Health Sciences
    • Dietetics, Nutrition and Biological Sciences
    • View Item
    •   QMU Repositories
    • eResearch
    • School of Health Sciences
    • Dietetics, Nutrition and Biological Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease

    Date
    2006-05
    Author
    Davidson, Isobel
    Robinson, S. D.
    Harding, S. A.
    Cummins, P.
    Din, J. N.
    Sarma, J.
    Fox, K. A. A.
    Boon, N. A.
    Newby, D. E.
    Metadata
    Show full item record
    Citation
    Davidson, I., Robinson, S., Harding, S., Cummins, P., Din, J., Sarma, J., Fox, K., Boon, N. & Newby, D. (2006) Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease, Platelets, vol. 17, , pp. 158-162,
    Abstract
    Platelet-monocyte binding and surface P-selectin expression are sensitive markers of platelet activation. Endothelium-derived factors are known to inhibit platelet activation and may confer important anti-atherothrombotic effects. We assessed the relationship between platelet activation and endothelium-dependent vasomotion in patients with coronary heart disease (CHD). Twenty male patients with stable CHD were compared with 20 healthy men. Platelet-monocyte binding and platelet surface expression of P-selectin were assessed using two-colour flow cytometry on whole blood. Forearm blood flow was assessed in patients using venous occlusion plethysmography during intra-arterial infusions of substance P, acetylcholine and sodium nitroprusside. Platelet activation was higher in patients than healthy men (platelet-monocyte binding, 27--3 vs. 20--1%; P-<-0.05). In patients with CHD, there was an inverse correlation between maximal substance P induced vasodilatation and both platelet-monocyte binding (P-=-0.003) and P-selectin expression (P-=-0.02). A similar correlation was observed between platelet-monocyte binding and the vasomotor response to acetylcholine (P-=-0.08) but not with sodium nitroprusside. In patients with stable coronary heart disease, there is a strong inverse relationship between markers of platelet activation and endothelium-dependent vasomotor function. This may explain the pathophysiological mechanism linking endothelial vasomotor dysfunction and the risk of acute atherothrombotic events.
    Official URL
    http://dx.doi.org/10.1080/17476930500454514
    URI
    http://www.informapharmascience.com/
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/104
    Collections
    • Dietetics, Nutrition and Biological Sciences

    Queen Margaret University: Research Repositories
    Accessibility Statement | Repository Policies | Contact Us | Send Feedback | HTML Sitemap

     

    Browse

    All QMU RepositoriesCommunities & CollectionsBy YearBy PersonBy TitleBy QMU AuthorBy Research CentreThis CollectionBy YearBy PersonBy TitleBy QMU AuthorBy Research Centre

    My Account

    LoginRegister

    Queen Margaret University: Research Repositories
    Accessibility Statement | Repository Policies | Contact Us | Send Feedback | HTML Sitemap