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dc.contributor.authorDavidson, Isobel
dc.contributor.authorRobinson, S. D.
dc.contributor.authorHarding, S. A.
dc.contributor.authorCummins, P.
dc.contributor.authorDin, J. N.
dc.contributor.authorSarma, J.
dc.contributor.authorFox, K. A. A.
dc.contributor.authorBoon, N. A.
dc.contributor.authorNewby, D. E.
dc.date.accessioned2018-06-29T21:34:18Z
dc.date.available2018-06-29T21:34:18Z
dc.date.issued2006-05
dc.identifierER104
dc.identifier.citationDavidson, I., Robinson, S., Harding, S., Cummins, P., Din, J., Sarma, J., Fox, K., Boon, N. & Newby, D. (2006) Functional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease, Platelets, vol. 17, , pp. 158-162,
dc.identifier.issn0953-7104
dc.identifier.urihttp://dx.doi.org/10.1080/17476930500454514
dc.identifier.urihttp://www.informapharmascience.com/
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/104
dc.description.abstractPlatelet-monocyte binding and surface P-selectin expression are sensitive markers of platelet activation. Endothelium-derived factors are known to inhibit platelet activation and may confer important anti-atherothrombotic effects. We assessed the relationship between platelet activation and endothelium-dependent vasomotion in patients with coronary heart disease (CHD). Twenty male patients with stable CHD were compared with 20 healthy men. Platelet-monocyte binding and platelet surface expression of P-selectin were assessed using two-colour flow cytometry on whole blood. Forearm blood flow was assessed in patients using venous occlusion plethysmography during intra-arterial infusions of substance P, acetylcholine and sodium nitroprusside. Platelet activation was higher in patients than healthy men (platelet-monocyte binding, 27--3 vs. 20--1%; P-<-0.05). In patients with CHD, there was an inverse correlation between maximal substance P induced vasodilatation and both platelet-monocyte binding (P-=-0.003) and P-selectin expression (P-=-0.02). A similar correlation was observed between platelet-monocyte binding and the vasomotor response to acetylcholine (P-=-0.08) but not with sodium nitroprusside. In patients with stable coronary heart disease, there is a strong inverse relationship between markers of platelet activation and endothelium-dependent vasomotor function. This may explain the pathophysiological mechanism linking endothelial vasomotor dysfunction and the risk of acute atherothrombotic events.
dc.format.extent158-162
dc.publisherTaylor & Francis
dc.relation.ispartofPlatelets
dc.subjectAtherosclerosis
dc.subjectcoronary disease
dc.subjectendothelial function
dc.subjectforearm blood flow
dc.subjectplatelets
dc.titleFunctional interplay between platelet activation and endothelial dysfunction in patients with coronary heart disease
dc.typearticle
dcterms.accessRightsnone
dc.description.facultysch_die
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dc.description.volume17
dc.identifier.doihttp://10.1080/17476930500454514
dc.description.ispublishedpub
dc.description.eprintid104
rioxxterms.typearticle
qmu.authorDavidson, Isobel
dc.description.statuspub
dc.description.number3


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