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dc.rights.licenseCreative Commons Attribution - Non Commercial (unported, v3.0) License
dc.contributor.authorMcLoone, Paulineen
dc.contributor.authorTabys, Dinaen
dc.contributor.authorFyfe, Lornaen
dc.date.accessioned2020-10-12T12:51:16Z
dc.date.available2020-10-12T12:51:16Z
dc.date.issued2020-11-24
dc.identifierhttps://eresearch.qmu.ac.uk/bitstream/handle/20.500.12289/10737/10737.pdf
dc.identifier.citationMcLoone, P., Tabys, D. & Fyfe, L. (2020) Honey combination therapies for skin and wound infecions: A systematic review of the literature. Clinical, Cosmetic and Investigational Dermatology, 13, pp. 875-888.en
dc.identifier.issn1178-7015en
dc.identifier.urihttps://doi.org/10.2147/CCID.S282143
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/10737
dc.descriptionReplaced AM with VoR 2020-11-24.
dc.description.abstractTopical application of medical grade honey is recommended for the clinical management of wound infections. The suitability of honey as a wound healing agent is largely due to its antibacterial activity, immune modulatory properties, and biocompatibility. Despite the usefulness of honey in wound healing, chronic wound infections continue to be a global problem requiring new and improved therapeutic interventions. Several recent studies have investigated the effects of combining honey with other therapies or agents with the aim of finding more efficacious treatments. In this systematic review, the database PubMed was used to carry out a search of the scientific literature on the combined effects of honey and other therapies on antimicrobial activity and wound and skin healing. The search revealed that synergistic or additive antimicrobial effects were observed in vitro when honey was combined with antibiotics, bacteriophages, antimicrobial peptides, natural agents e.g. ginger or propolis and other treatment approaches such as the use of chitosan hydrogel. Outcomes depended on the type of honey, the combining agent or treatment and the microbial species or strain. Improved wound healing was also observed in vivo in mice when honey was combined with laser therapy or bacteriophage therapy. More clinical studies in humans are required to fully understand the effectiveness of honey combination therapies for the treatment of skin and wound infections.en
dc.description.urihttps://doi.org/10.2147/CCID.S282143en
dc.format.extent875-888
dc.language.isoenen
dc.publisherDove Medical Pressen
dc.relation.ispartofClinical, Cosmetic and Investigational Dermatologyen
dc.rights© 2020 McLoone et al.
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subjectHoneyen
dc.subjectAntibioticsen
dc.subjectNatural Agentsen
dc.subjectCombination Therapyen
dc.subjectWound Infectionen
dc.subjectSkin Infectionen
dc.titleHoney combination therapies for skin and wound infections: A systematic review of the literatureen
dc.typeArticleen
dcterms.accessRightspublic
dcterms.dateAccepted2020-10-10
dc.date.updated2020-11-24
dc.description.volume13
dc.description.ispublishedpub
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2020-11-24
refterms.dateFCD2020-10-12
refterms.depositExceptionpublishedGoldOAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorFyfe, Lornaen
qmu.centreCentre for Health, Activity and Rehabilitation Researchen
dc.description.statuspub
refterms.versionVoRen
refterms.dateDeposit2020-10-12


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Creative Commons Attribution - Non Commercial (unported, v3.0) License
Except where otherwise noted, this item's license is described as Creative Commons Attribution - Non Commercial (unported, v3.0) License