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dc.rights.licenseCC-BY-NC-ND 4.0
dc.contributor.authorAndreopoulou, Georgiaen
dc.contributor.authorMercer, Tomen
dc.contributor.authorGuerrero Enriquez, Juliaen
dc.contributor.authorJustin, Matthewen
dc.contributor.authorMacLeod, Nicolaen
dc.contributor.authorHarrison, Emilyen
dc.contributor.authorMahad, Don J.en
dc.contributor.authorvan der Linden, Mariettaen
dc.date.accessioned2020-11-19T15:45:05Z
dc.date.available2020-11-19T15:45:05Z
dc.date.issued2020-11-19
dc.identifierhttps://eresearch.qmu.ac.uk/bitstream/handle/20.500.12289/10877/10877.pdf
dc.identifier.citationAndreopoulou, G., Mercer, T., Guerrero Enriquez, J., Justin, M., MacLeod, N., Harrison, E., Mahad, D. J. & van der Linden, M. (2020) Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability. Multiple Sclerosis and Related Disorders (In Press).en
dc.identifier.issn2211-0348en
dc.identifier.urihttps://doi.org/10.1016/j.msard.2020.102630
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/10877
dc.descriptionMarietta van der Linden - ORCID 0000-0003-2256-6673 https://orcid.org/0000-0003-2256-6673en
dc.description.abstractBackground Exercise-induced gait deterioration is a frequently encountered symptom that limits ambulation throughout the clinical course, becoming more prominent with increasing neurological disability in people with MS (pwMS).en
dc.description.abstractObjective We attempted to objectively document exercise-induced gait changes in pwMS with minimal neurological disability and stable disease.
dc.description.abstractMethods Gait kinematics and spatio-temporal parameters were recorded using 3D motion analysis before and after a 20-minute treadmill walk (Group A, n=15)/run (Group B, n=15) at a self-selected speed in pwMS and compared with healthy controls (n=15).
dc.description.abstractResults Gait analysis revealed a significant decrease in peak ankle dorsiflexion in swing of the most affected leg, post-exercise task, in both Group A (EDSS 2.5-3.5) and Group B (EDSS 1-2.5) and not in healthy controls. Fourteen out of 30 MS participants showed an exercise-induced gait deterioration, based on minimal detectable change. Pre-exercise gait parameters in Group A showed a significantly higher peak dorsiflexion in swing with shorter step length and higher cadence, whereas Group B was comparable to healthy controls.
dc.description.abstractConclusion The detection of exercise-induced gait deterioration (foot drop) in pwMS with minimal neurological disability and stable disease indicates the potential of gait kinematics, before and after an exercise task, to monitor subtle neurological deficits from an early stage of MS.
dc.description.urihttps://doi.org/10.1016/j.msard.2020.102630en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofMultiple Sclerosis and Related Disordersen
dc.rights© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMultiple Sclerosisen
dc.subjectMinimal Disabilityen
dc.subjectGait Kinematicsen
dc.subjectExerciseen
dc.subjectFoot Dropen
dc.subjectFatigabilityen
dc.titleExercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disabilityen
dc.typeArticleen
dcterms.accessRightsrestricted
dcterms.dateAccepted2020-11-12
dc.description.ispublishedinpress
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2020-11-19
refterms.dateEmbargoEnd2021-11-19
refterms.dateFCD2020-11-19
refterms.depositExceptionNAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorAndreopoulou, Georgiaen
qmu.authorMercer, Tomen
qmu.authorvan der Linden, Mariettaen
qmu.centreCentre for Health, Activity and Rehabilitation Researchen
dc.description.statusinpress
refterms.versionAMen
refterms.dateDeposit2020-11-19


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Except where otherwise noted, this item's license is described as CC-BY-NC-ND 4.0