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dc.rights.licenseCC BY license
dc.contributor.authorGreenwood, Sharlene A.en
dc.contributor.authorKoufaki, Pelagiaen
dc.contributor.authorMacdonald, Jamieen
dc.contributor.authorBhandari, Sunilen
dc.contributor.authorBurton, Jamesen
dc.contributor.authorDasgupta, Indranilen
dc.contributor.authorFarrington, Kennethen
dc.contributor.authorFord, Ianen
dc.contributor.authorKalra, Philip A.en
dc.contributor.authorKean, Sharonen
dc.contributor.authorKumwenda, Micken
dc.contributor.authorMacdougall, Iain C.en
dc.contributor.authorMessow, Claudia-Martinaen
dc.contributor.authorMitra, Sandipen
dc.contributor.authorReid, Chanteen
dc.contributor.authorSmith, Alice C.en
dc.contributor.authorTaal, Maarten W.en
dc.contributor.authorThomson, Peter C.en
dc.contributor.authorWheeler, David C.en
dc.contributor.authorWhite, Claireen
dc.contributor.authorYaqoob, Magdien
dc.contributor.authorMercer, Tomen
dc.identifier.citationGreenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J., Dasgupta, I., Farrington, K., Ford, I., Kalra, P. A., Kean, S., Kumwenda, M., Macdougall, I. C., Messow, C.-M., Mitra, S. Reid, C., Smith, A. C., Taal, M. W., Thomson, P. C., Wheeler, D. C., White, C., Yaqoob, M. & Mercer, T. (2021) Randomized Trial—PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysis. Kidney International Reports, 6(8), pp. 2159-2170.en
dc.descriptionPelagia Koufaki - ORCID: 0000-0002-1406-3729
dc.descriptionTom Mercer - ORCID: 0000-0002-5078-4769
dc.description.abstractIntroduction: Whether clinically implementable exercise interventions in people receiving hemodialysis (HD) therapy improve health-related quality of life (HRQoL) remains unknown. The PrEscription of intraDialytic exercise to improve quAlity of Life (PEDAL) study evaluated the clinical benefit and costeffectiveness of a 6-month intradialytic exercise program.en
dc.description.abstractMethods: In a multicenter, single-blinded, randomized, controlled trial, people receiving HD were randomly assigned to (i) intradialytic exercise training (exercise intervention group [EX]) and (ii) usual care (control group [CON]). Primary outcome was change in Kidney Disease Quality of Life Short-Form Physical Component Summary (KDQOL-SF 1.3 PCS) from baseline to 6 months. Cost-effectiveness was determined using health economic analysis; physiological impairment was evaluated by peak oxygen uptake; and harms were recorded.
dc.description.abstractResults: We randomized 379 participants; 335 and 243 patients (EX n ¼ 127; CON n ¼ 116) completed baseline and 6-month assessments, respectively. Mean difference in change PCS from baseline to 6 months between EX and CON was 2.4 (95% confidence interval [CI]: 0.1 to 4.8) arbitrary units (P ¼ 0.055); no improvements were observed in peak oxygen uptake or secondary outcome measures. Participants in the intervention group had poor compliance (47%) and poor adherence (18%) to the exercise prescription. Cost of delivering intervention ranged from US$598 to US$1092 per participant per year. The number of participants with harms was similar between EX (n ¼ 69) and CON (n ¼ 56). A primary limitation was the lack of an attention CON. Many patients also withdrew from the study or were too unwell to complete all physiological outcome assessments.
dc.description.abstractConclusions: A 6-month intradialytic aerobic exercise program was not clinically beneficial in improving HRQoL as delivered to this cohort of deconditioned patients on HD.
dc.description.sponsorshipThis study is funded by a grant from the National Institute for Health Research (grant number: NIHR-HTA 12/23/09).en
dc.publisherInternational Society of Nephrologyen
dc.relation.ispartofKidney International Reportsen
dc.subjectChronic Kidney Diseaseen
dc.subjectPhysical Activityen
dc.subjectPhysical Functionen
dc.titleRandomized Trial—PrEscription of intraDialytic exercise to improve quAlity of Life in Patients Receiving Hemodialysisen
dc.rights.holder(c) 2021 International Society of Nephrology
rioxxterms.typeJournal Article/Reviewen
qmu.authorKoufaki, Pelagiaen
qmu.authorMercer, Tomen
qmu.centreCentre for Health, Activity and Rehabilitation Researchen
qmu.centreCentre for Health, Activity and Rehabilitation Research

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