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dc.rights.licenseCreative Commons Attribution-NonCommercial-NoDerivs License
dc.contributor.authorHall, Charlie C.
dc.contributor.authorSkipworth, Richard J.E.
dc.contributor.authorBlackwood, Honor
dc.contributor.authorBrown, Duncan
dc.contributor.authorCook, Jane
dc.contributor.authorDiernberger, Katharina
dc.contributor.authorDixon, Elizabeth
dc.contributor.authorGibson, Valerie
dc.contributor.authorGraham, Catriona
dc.contributor.authorHall, Peter
dc.contributor.authorHaraldsdottir, Erna
dc.contributor.authorHopkinson, Jane
dc.contributor.authorLloyd, Anna
dc.contributor.authorMaddocks, Matthew
dc.contributor.authorNorris, Lucy
dc.contributor.authorTuck, Sharon
dc.contributor.authorFallon, Marie T.
dc.contributor.authorLaird, Barry J.A.
dc.date.accessioned2021-10-12T10:04:47Z
dc.date.available2021-10-12T10:04:47Z
dc.date.issued2021-10-05
dc.date.submitted2021-06-08
dc.identifierhttps://eresearch.qmu.ac.uk/bitstream/handle/20.500.12289/11528/11528.pdf
dc.identifier.citationHall, C.C., Skipworth, R.J.E., Blackwood, H., Brown, D., Cook, J., Diernberger, K., Dixon, E., Gibson, V., Graham, C., Hall, P., Haraldsdottir, E., Hopkinson, J., Lloyd, A., Maddocks, M., Norris, L., Tuck, S., Fallon, M.T. and Laird, B.J.A. (2021) ‘A randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer’, Journal of Cachexia, Sarcopenia and Muscle (In Press).
dc.identifier.issn2190-6009
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/11528
dc.identifier.urihttps://doi.org/10.1002/jcsm.12806
dc.descriptionFrom Wiley via Jisc Publications Router
dc.descriptionErna Haraldsdottir - ORCID: 0000-0003-4891-0743 https://orcid.org/0000-0003-4891-0743
dc.description.abstractBackground: Despite rehabilitation being increasingly advocated for people living with incurable cancer, there is limited evidence supporting efficacy or component parts. The progressive decline in function and nutritional in this population would support an approach that targets these factors. This trial aimed to assess the feasibility of an exercise and nutrition based rehabilitation programme in people with incurable cancer. Methods: We randomized community dwelling adults with incurable cancer to either a personalized exercise and nutrition based programme (experimental arm) or standard care (control arm) for 8 weeks. Endpoints included feasibility, quality of life, physical activity (step count), and body weight. Qualitative and health economic analyses were also included. Results: Forty‐five patients were recruited (23 experimental arm, 22 control arm). There were 26 men (58%), and the median age was 78 years (IQR 69–84). At baseline, the median BMI was 26 kg/m2 (IQR: 22–29), and median weight loss in the previous 6 months was 5% (IQR: −12% to 0%). Adherence to the experimental arm was >80% in 16/21 (76%) patients. There was no statistically significant difference in the following between trial arms: step count − median % change from baseline to endpoint, per trial arm (experimental −18.5% [IQR: −61 to 65], control 5% [IQR: −32 to 50], P = 0.548); weight − median % change from baseline to endpoint, per trial arm (experimental 1%[IQR: −3 to 3], control −0.5% [IQR: −3 to 1], P = 0.184); overall quality of life − median % change from baseline to endpoint, per trial arm (experimental 0% [IQR: −20 to 19], control 0% [IQR: −23 to 33], P = 0.846). Qualitative findings observed themes of capability, opportunity, and motivation amongst patients in the experimental arm. The mean incremental cost of the experimental arm versus control was £‐319.51 [CI −7593.53 to 6581.91], suggesting the experimental arm was less costly. Conclusions: An exercise and nutritional rehabilitation intervention is feasible and has potential benefits for people with incurable cancer. A larger trial is now warranted to test the efficacy of this approach.
dc.languageen
dc.publisherWiley
dc.publisherSociety on Sarcopenia, Cachexia and Wasting Disorders
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectExercise
dc.subjectNutrition
dc.subjectCancer
dc.subjectRehabilitation
dc.titleA randomized, feasibility trial of an exercise and nutrition‐based rehabilitation programme (ENeRgy) in people with cancer
dc.typeArticle
dcterms.accessRightspublic
dcterms.dateAccepted2021-08-23
dc.date.updated2021-10-06T04:06:33Z
dc.description.ispublishedaheadofprint
rioxxterms.publicationdate2021-10-05
refterms.dateFCD2021-10-12
refterms.depositExceptionpublishedGoldOA
qmu.authorHaraldsdottir, Erna
qmu.authorLloyd, Anna
qmu.centreCentre for Person-centred Practise Research
dc.description.statusaheadofprint
refterms.versionVoR
refterms.dateDeposit2021-10-12


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