Show simple item record

dc.rights.licenseCreative Commons Attribution 4.0 International License
dc.contributor.authorMaarj, Muhammad
dc.contributor.authorCoda, Andrea
dc.contributor.authorTofts, Louise
dc.contributor.authorWilliams, Cylie
dc.contributor.authorSantos, Derek
dc.contributor.authorPacey, Verity
dc.date.accessioned2021-12-06T15:57:25Z
dc.date.available2021-12-06T15:57:25Z
dc.date.issued2021-11-29
dc.date.submitted2021-02-18
dc.identifierpublisher-id: s12887-021-03009-z
dc.identifiermanuscript: 3009
dc.identifierdoi: 10.1186/s12887-021-03009-z
dc.identifierhttps://eresearch.qmu.ac.uk/bitstream/handle/20.500.12289/11614/11614.pdf
dc.identifier.citationMaarj, M., Coda, A., Tofts, L., Williams, C., Santos, D. & Pacey, V. (2021) 'Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: A systematic review', BMC Pediatrics, 21, article no. 527
dc.identifier.issn1471-2431
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/11614
dc.identifier.urihttps://doi.org/10.1186/s12887-021-03009-z
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2021-02-18, accepted 2021-11-15, registration 2021-11-16, pub-electronic 2021-11-29, online 2021-11-29, collection 2021-12
dc.descriptionPublication status: Published
dc.description.abstractBackground: Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower limb symptoms. Methods: Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5 and 18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist. Results: Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 and 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions: There were no agreed sets of outcome measures used for children with GJH and symptoms. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools.
dc.description.urihttps://doi.org/10.1186/s12887-021-03009-z
dc.languageen
dc.publisherBioMed Central
dc.relation.ispartofBMC Pediatrics
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1471-2431
dc.subjectResearch Article
dc.subjectFatigue
dc.subjectOutcome Measures
dc.subjectPaediatrics
dc.subjectHypermobility
dc.subjectPain
dc.subjectFunction
dc.subjectQuality Of Life
dc.titleOutcome measures for assessing change over time in studies of symptomatic children with hypermobility: A systematic review
dc.typeArticle
dcterms.accessRightspublic
dcterms.dateAccepted2021-11-15
dc.date.updated2021-12-03T16:16:02Z
dc.description.volume21
dc.description.ispublishedpub
rioxxterms.publicationdate2021-11-29
refterms.dateFCD2021-12-06
refterms.depositExceptionpublishedGoldOA
qmu.authorSantos, Derek
qmu.centreCentre for Health, Activity and Rehabilitation Research
dc.description.statuspub
refterms.versionVoR
refterms.dateDeposit2021-12-06


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License