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dc.rights.licenseCreative Commons Attribution License
dc.contributor.authorThomas, Fawzi
dc.contributor.authorAbiri, Onome T.
dc.contributor.authorKomeh, James P.
dc.contributor.authorConteh, Thomas A.
dc.contributor.authorBah, Abdulai Jawo
dc.contributor.authorKanu, Joseph Sam
dc.contributor.authorTerry, Robert
dc.contributor.authorAbrahamyan, Arpine
dc.contributor.authorThekkur, Pruthu
dc.contributor.authorZachariah, Rony
dc.date.accessioned2022-03-17T14:11:32Z
dc.date.available2022-03-17T14:11:32Z
dc.date.issued2022-03-10
dc.identifierdoi: 10.3390/ijerph19063264
dc.identifierhttps://eresearch.qmu.ac.uk/bitstream/handle/20.500.12289/11956/11956.pdf
dc.identifier.citationThomas, F., Abiri, O.T., Komeh, J.P., Conteh, T.A., Bah, A.J., Kanu, J.S., Terry, R., Abrahamyan, A., Thekkur, P. and Zachariah, R. (2022) ‘Inconsistent country-wide reporting of adverse drug reactions to antimicrobials in Sierra Leone (2017–2021): A wake-up call to improve reporting’, International Journal of Environmental Research and Public Health, 19(6), article no. e3264.
dc.identifier.issn1660-4601
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/11956
dc.identifier.urihttps://doi.org/10.3390/ijerph19063264
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2022-03-08, pub-electronic 2022-03-10
dc.descriptionPublication status: Published
dc.description.abstractBackground: Monitoring of adverse drug reactions (ADRs) to antimicrobials is important, as they can cause life-threatening illness, permanent disabilities, and death. We assessed country-wide ADR reporting on antimicrobials and their outcomes. Methods: A cross-sectional study was conducted using individual case safety reports (ICSRs) entered into the national pharmacovigilance database (VigiFlow) during 2017−2021. Results: Of 566 ICSRs, inconsistent reporting was seen, with the highest reporting in 2017 and 2019 (mass drug campaigns for deworming), zero reporting in 2018 (reasons unknown), and only a handful in 2020 and 2021 (since COVID-19). Of 566 ICSRs, 90% were for antiparasitics (actively reported during mass campaigns), while the rest (passive reporting from health facilities) included 8% antibiotics, 7% antivirals, and 0.2% antifungals. In total, 90% of the reports took >30 days to be entered (median = 165; range 2−420 days), while 44% had 75% of all variables filled in (desired target = 100%). There were 10 serious ADRs, 18 drug withdrawals, and 60% of ADRs affected the gastrointestinal system. The patient outcomes (N-566) were: recovered (59.5%), recovering (35.5%), not recovered (1.4%), death (0.2%), and unknown (3.4%). There was no final ascertainment of ‘recovering’ outcomes. Conclusions: ADR reporting is inconsistent, with delays and incomplete data. This is a wake-up call for introducing active reporting and setting performance targets.
dc.languageen
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Environmental Research and Public Health
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1660-4601
dc.subjectSORT IT
dc.subjectOperational Research
dc.subjectVigiBase
dc.subjectHealth System Strengthening
dc.subjectUniversal Health Coverage
dc.titleInconsistent country-wide reporting of adverse drug reactions to antimicrobials in Sierra Leone (2017–2021): A wake-up call to improve reporting
dc.typeArticle
dcterms.accessRightspublic
dcterms.dateAccepted2022-03-08
dc.date.updated2022-03-12T03:30:12Z
dc.description.volume19
dc.description.ispublishedpub
rioxxterms.publicationdate2022-03-10
refterms.dateFCD2022-03-17
refterms.depositExceptionpublishedGoldOA
qmu.authorBah, Abdulai Jawo
qmu.centreInstitute for Global Health and Development
dc.description.statuspub
dc.description.number6
refterms.versionVoR
refterms.dateDeposit2022-03-17


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