Show simple item record

dc.contributor.authorWood, Adrian D.en
dc.contributor.authorGryka-MacPhail, Annaen
dc.contributor.authorThies, Franken
dc.contributor.authorAucott, Lorna S.en
dc.contributor.authorReid, David M.en
dc.contributor.authorHardcastle, Antonia C.en
dc.contributor.authorMavroeidi, Alexandraen
dc.contributor.authorSimpson, William G.en
dc.contributor.authorDuthie, Garry G.en
dc.contributor.authorMacdonald, Helen M.en
dc.date.accessioned2022-03-31T13:36:47Z
dc.date.available2022-03-31T13:36:47Z
dc.date.issued2014-09-15
dc.identifier.citationWood, A.D., Gryka-MacPhail, A., Thies, F., Aucott, L.S., Reid, D.M., Hardcastle, A.C., Mavroeidi, A., Simpson, W.G., Duthie, G.G. and Macdonald, H.M. (2014) ‘Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk’, British Journal of Nutrition, 112(8), pp. 1341-1352.en
dc.identifier.issn0007-1145en
dc.identifier.issn1475-2662
dc.identifier.urihttps://doi.org/10.1017/S0007114514001962
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/11972
dc.descriptionItem not available in this repository.en
dc.description.abstractDietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined the relationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemic inflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237, mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessed by FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A, E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid) components were generated by principal components analysis. A past ‘prudent’ dietary pattern predicted serum concentrations of hs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P= 0·002 and P= 0·001, respectively; ANCOVA). Contemporary dietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintiles of the ‘prudent’ dietary pattern (P= 0·030 and P= 0·006, respectively). hs-CRP concentration increased across the quintiles of a ‘meat-dominated’ dietary pattern (P= 0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoid component score (P< 0·001 for hs-CRP and IL-6, and P= 0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid component scores were negatively associated with serum hs-CRP concentration (unstandardised β for prudent component: − 0·053, 95 % CI − 0·102, − 0·003; carotenoid component: − 0·183, 95 % CI − 0·233, − 0·134) independent of study covariates. A prudent dietary pattern (which reflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and a serum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markers that are indicative of CVD risk reduction.en
dc.description.sponsorshipThe present study was supported by the Food Standards Agency and the UK Department of Health (grant no. N05086) and the Scottish Funding Council. G. G. D. and F. T. are grateful for support from the Scottish Government (Rural and Environmental Science and Analytical Services). None of the funders had a role in the design and analysis of the study or in the writing of this article.en
dc.description.urihttps://doi.org/10.1017/S0007114514001962en
dc.format.extent1341-1352en
dc.language.isoenen
dc.publisherThe Nutrition Societyen
dc.relation.ispartofBritish Journal of Nutritionen
dc.subjectDietary Patternsen
dc.subjectCarotenoidsen
dc.subjectSystemic Inflammationen
dc.subjectCVD Risken
dc.subjectPostmenopausal Womenen
dc.subjectLongitudinal Studiesen
dc.titlePatterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risken
dc.typeArticleen
dcterms.accessRightsnone
dcterms.dateAccepted2014-06-13
dc.description.volume112en
dc.description.ispublishedpub
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2014-09-15
refterms.depositExceptionNAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorGryka-MacPhail, Annaen
dc.description.statuspub
dc.description.number8en
refterms.versionNAen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record