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dc.contributor.authorWilson, Ronaen
dc.contributor.authorPlinston, Chrisen
dc.contributor.authorHunter, Noraen
dc.contributor.authorCasalone, Cristinaen
dc.contributor.authorCorona, Cristianoen
dc.contributor.authorTagliavini, Fabrizioen
dc.contributor.authorSuardi, SIlviaen
dc.contributor.authorRuggerone, Margheritaen
dc.contributor.authorGraziano, Silviaen
dc.contributor.authorSbriccoli, Marcoen
dc.contributor.authorCardone, Francoen
dc.contributor.authorPocchiari, Maurizioen
dc.contributor.authorIngrosso, Loredanaen
dc.contributor.authorBaron, Thierryen
dc.contributor.authorRicht, Juergenen
dc.contributor.authorAndreoletti, Olivieren
dc.contributor.authorSimmons, Marionen
dc.contributor.authorLockey, Richarden
dc.contributor.authorManson, Jean C.en
dc.contributor.authorBarron, Ronaen
dc.identifier.citationWilson, R., Plinston, C., Hunter, N., Casalone, C., Corona, C., Tagliavini, F., Suardi, S., Ruggerone, M., Moda, F., Graziano, S., Sbriccoli, M., Cardone, F., Pocchiari, M., Ingrosso, L., Baron, T., Richt, J., Andreoletti, O., Simmons, M., Lockey, R., Manson, J.C. and Barron, R.M. (2012) ‘Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein’, Journal of General Virology, 93(7), pp. 1624–1629. Available at:
dc.descriptionRona Barron - ORCID: 0000-0003-4512-9177
dc.descriptionItem not available in this repository.en
dc.description.abstractThe association between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob disease (vCJD) has demonstrated that cattle transmissible spongiform encephalopathies (TSEs) can pose a risk to human health and raises the possibility that other ruminant TSEs may be transmissible to humans. In recent years, several novel TSEs in sheep, cattle and deer have been described and the risk posed to humans by these agents is currently unknown. In this study, we inoculated two forms of atypical BSE (BASE and H-type BSE), a chronic wasting disease (CWD) isolate and seven isolates of atypical scrapie into gene-targeted transgenic (Tg) mice expressing the human prion protein (PrP). Upon challenge with these ruminant TSEs, gene-targeted Tg mice expressing human PrP did not show any signs of disease pathology. These data strongly suggest the presence of a substantial transmission barrier between these recently identified ruminant TSEs and humans.en
dc.publisherMicrobiology Societyen
dc.relation.ispartofJournal of General Virologyen
dc.titleChronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion proteinen
rioxxterms.typeJournal Article/Reviewen
qmu.authorModa, Fabioen

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