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dc.contributor.authorPlinston, Chrisen
dc.contributor.authorHart, Patriciaen
dc.contributor.authorChong, Angelaen
dc.contributor.authorPiccardo, Pedroen
dc.contributor.authorHunter, Noraen
dc.contributor.authorFoster, Jamesen
dc.contributor.authorManson, Jean C.en
dc.contributor.authorBarron, Ronaen
dc.identifier.citationPlinston, C., Hart, P., Chong, A., Hunter, N., Foster, J., Piccardo, P., Manson, J.C. and Barron, R.M. (2011) ‘Increased susceptibility of human-prp transgenic mice to bovine spongiform encephalopathy infection following passage in sheep’, Journal of Virology, 85(3), pp. 1174–1181. Available at:
dc.descriptionRona Barron - ORCID: 0000-0003-4512-9177
dc.descriptionItem not available in this repository.en
dc.description.abstractThe risk of the transmission of ruminant transmissible spongiform encephalopathy (TSE) to humans was thought to be low due to the lack of association between sheep scrapie and the incidence of human TSE. However, a single TSE agent strain has been shown to cause both bovine spongiform encephalopathy (BSE) and human vCJD, indicating that some ruminant TSEs are transmissible to humans. While the transmission of cattle BSE to humans in transgenic mouse models has been inefficient, indicating the presence of a significant transmission barrier between cattle and humans, BSE has been transmitted to a number of other species. Here, we aimed to further investigate the human transmission barrier following the passage of BSE in a sheep. Following inoculation with cattle BSE, gene-targeted transgenic mice expressing human PrP showed no clinical or pathological signs of TSE disease. However, following inoculation with an isolate of BSE that had been passaged through a sheep, TSE-associated vacuolation and proteinase K-resistant PrP deposition were observed in mice homozygous for the codon 129-methionine PRNP gene. This observation may be due to higher titers of the BSE agent in sheep or an increased susceptibility of humans to BSE prions following passage through a sheep. However, these data confirm that, contrary to previous predictions, it is possible that a sheep prion is transmissible to humans and that BSE from other species is a public health risk.en
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofJournal of Virologyen
dc.titleIncreased Susceptibility of Human-PrP Transgenic Mice to Bovine Spongiform Encephalopathy Infection following Passage in Sheepen
rioxxterms.typeJournal Article/Reviewen

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