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dc.contributor.authorHuët, Marie Andrea Laetitiaen
dc.contributor.authorWong, Li Wenen
dc.contributor.authorGoh, Calvin Bok Sunen
dc.contributor.authorHussain, Md Hameden
dc.contributor.authorMuzahid, Nazmul Hasanen
dc.contributor.authorDwiyanto, Jackyen
dc.contributor.authorLee, Shaun Wen Hueyen
dc.contributor.authorAyub, Qasimen
dc.contributor.authorReidpath, Danielen
dc.contributor.authorLee, Sui Maeen
dc.contributor.authorRahman, Sadequren
dc.contributor.authorTan, Joash Ban Leeen
dc.identifier.citationHuët, M.A.L., Wong, L.W., Goh, C.B.S., Hussain, M.H., Muzahid, N.H., Dwiyanto, J., Lee, S.W.H., Ayub, Q., Reidpath, D., Lee, S.M., Rahman, S. and Tan, J.B.L. (2021) ‘Investigation of culturable human gut mycobiota from the segamat community in Johor, Malaysia’, World Journal of Microbiology and Biotechnology, 37(7), p. 113. Available at:
dc.descriptionDaniel Reidpath - ORCID: 0000-0002-8796-0420
dc.descriptionItem is not available in this repository.en
dc.description.abstractAlthough several studies have already been carried out in investigating the general profile of the gut mycobiome across several countries, there has yet to be an officially established baseline of a healthy human gut mycobiome, to the best of our knowledge. Microbial composition within the gastrointestinal tract differ across individuals worldwide, and most human gut fungi studies concentrate specifically on individuals from developed countries or diseased cohorts. The present study is the first culture-dependent community study assessing the prevalence and diversity of gut fungi among different ethnic groups from South East Asia. Samples were obtained from a multi-ethnic semi-rural community from Segamat in southern Malaysia. Faecal samples were screened for culturable fungi and questionnaire data analysis was performed. Culturable fungi were present in 45% of the participants’ stool samples. Ethnicity had an impact on fungal prevalence and density in stool samples. The prevalence of resistance to fluconazole, itraconazole, voriconazole and 5-fluorocytosine, from the Segamat community, were 14%, 14%, 11% and 7% respectively. It was found that Jakun individuals had lower levels of antifungal resistance irrespective of the drug tested, and male participants had more fluconazole resistant yeast in their stool samples. Two novel point mutations were identified in the ERG11 gene from one azole resistant Candida glabrata, suggesting a possible cause of the occurrence of antifungal resistant isolates in the participant’s faecal sample.en
dc.relation.ispartofWorld Journal of Microbiology and Biotechnologyen
dc.titleInvestigation of culturable human gut mycobiota from the segamat community in Johor, Malaysiaen
rioxxterms.typeJournal Article/Reviewen

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