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    Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy – a five-year observational study

    Date
    2014-10-02
    Author
    Naftalin, Claire M
    Wong, Ngai Sze
    Chan, Denise PC
    Wong, Ka Hing
    Reidpath, Daniel
    Lee, Shui Shan
    Metadata
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    Citation
    Naftalin, C.M., Wong, N.S., Chan, D.P., Wong, K.H., Reidpath, D.D. and Lee, S.S. (2015) ‘Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy – a five-year observational study’, International Journal of STD & AIDS, 26(11), pp. 803–809. Available at: https://doi.org/10.1177/0956462414553826.
    Abstract
    To explore the heterogeneity of CD4 responses following highly active antiretroviral therapy, the patterns of CD4 recovery of HIV-1-infected Chinese patients who have been on their first antiretroviral regimen for ≥5 years were analysed. The CD4 trajectories were traced, smoothed and differentiated into three defined profiles. Half (56.3%) were ‘satisfactory responders’, with CD4 gain of >100 cells/μL and a peak of >350 cells/μL, plateauing before the end of Year 5. Thirty-three (24.4%) were ‘continuing responders’ whose CD4 rise persisted at Year 4–5. The remaining 26 (19.3%) were ‘poor responders’. Presentation with AIDS before therapy was common not just among ‘poor’ but also paradoxically the ‘continuing’ responders. While a majority had responded well to antiretroviral therapy, older patients and those with AIDS diagnosis before initiation of therapy may never achieve a satisfactory level even with effective treatment. Categorization of HIV patients by their CD4 trajectory may support the prediction of immunological outcome over time, and ultimately inform treatment choices.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/12931
    Official URL
    https://doi.org/10.1177/0956462414553826
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