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dc.contributor.authorAlmoosawi, Suzana
dc.contributor.authorTsang, Catherine
dc.contributor.authorOstertag, L. M.
dc.contributor.authorFyfe, Lorna
dc.contributor.authorAl-Dujaili, Emad A. S.
dc.date.accessioned2018-06-29T21:33:06Z
dc.date.available2018-06-29T21:33:06Z
dc.date.issued2012-07
dc.identifierER2420
dc.identifier.citationAlmoosawi, S., Tsang, C., Ostertag, L., Fyfe, L. & Al-Dujaili, E. (2012) Differential effect of polyphenol-rich dark chocolate on glucoregulatory and cardiovascular risk factors on healthy overweight and obese subjects: a randomized clinical trial, Food and Function, vol. 3, , pp. 1035-1043,
dc.identifier.issn2042-6496
dc.identifier.urihttp://dx.doi.org/10.1039/C2FO30060E
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/2420
dc.description.abstractThe association between excess cortisol and various parameters of metabolic syndrome including hypertension, insulin resistance and dyslipidaemia is increasingly recognised. The present single-blind randomised placebo-controlled cross-over study compared the effect of polyphenol-rich dark chocolate (DC) on biomarkers of glucose metabolism, lipid profile, and blood pressure (BP) in females with BMI 25 kg m-2 (n = 21) and females with BMI < 25 kg m-2 (n = 21). Volunteers consumed 20 g of DC containing 500 mg polyphenols or a placebo DC with negligible polyphenol-content daily for 4 weeks, separated by a 2-week washout period. Systolic BP and diastolic BP decreased after 4 weeks of polyphenol-rich DC. Placebo raised fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and salivary cortisol, an effect that was significantly different from polyphenol-rich DC which had a negligible effect on fasting insulin, HOMA-IR and salivary cortisol. Females with BMI 25 kg m-2 responded less favourably to placebo than lean females and consequently had higher fasting insulin and HOMA-IR, in addition to a lower quantitative sensitivity check index (QUICKI) after ingestion of placebo compared to polyphenol-rich DC. No significant changes in lipid profile were observed. This study provides evidence for the metabolic benefits of consuming polyphenol-rich dark chocolate while demonstrating the possibility of adverse effects occurring with polyphenol-poor chocolate placebo.
dc.description.abstractPaper adds to the growing body of evidence that children can acquire phonological systems before they are able to master the phonetic skills needed to convey the contrasts in that system
dc.format.extent1035-1043
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofFood and Function
dc.titleDifferential effect of polyphenol-rich dark chocolate on glucoregulatory and cardiovascular risk factors on healthy overweight and obese subjects: a randomized clinical trial
dc.typearticle
dcterms.accessRightspublic
dc.description.facultysch_die
dc.description.volume3
dc.identifier.doihttp://10.1039/C2FO30060E
dc.description.ispublishedpub
dc.description.eprintid2420
rioxxterms.typearticle
qmu.authorAl-Dujaili, Emad A. S.
qmu.authorAlmoosawi, Suzana
qmu.authorTsang, Catherine
qmu.authorFyfe, Lorna
dc.description.statuspub
dc.description.number10


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