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dc.contributor.authorChick, Jonathan
dc.contributor.authorNutt, David J.
dc.date.accessioned2018-06-29T21:36:47Z
dc.date.available2018-06-29T21:36:47Z
dc.date.issued2012-02
dc.identifierER2663
dc.identifier.citationChick, J. & Nutt, D. (2012) Substitution therapy for alcoholism: time for a reappraisal?, Journal of Psychopharmacology, vol. 26, , pp. 205-212,
dc.identifier.issn2698811
dc.identifier.urihttps://doi.org/10.1177/0269881111408463
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/2663
dc.description.abstractA number of compounds already in use as medications for various indications substitute for ethanol at clinically relevant brain pathways, in particular, at gamma-aminobutyric acid (GABA) receptors. Nevertheless, although substitute medications have been recognized for heroin and tobacco dependence, patients with alcohol dependence are rarely offered an analogous approach. Benzodiazepines may have paradoxical effects, and abuse and dependence are known. Baclofen (GABAB agonist) has not been associated with dependence or misuse and has been effective in several trials in preventing relapse, although research is required to establish the optimal dosing regimen. GABA-ergic anticonvulsants, helpful in treating withdrawal, have yet to emerge as effective in relapse prevention. Clomethiazole and sodium oxybate, the latter having been shown to be effective in relapse prevention, have incurred a reputation for dependence and abuse. However, data have emerged showing that the risk of abuse of sodium oxybate is lower than many clinicians had foreseen. For a condition where existing therapies are only effective in a proportion of patients, and which has high morbidity and mortality, the time now seems right for reappraising the use of substitute prescribing for alcohol dependence.
dc.format.extent205-212
dc.publisherSage
dc.relation.ispartofJournal of Psychopharmacology
dc.titleSubstitution therapy for alcoholism: time for a reappraisal?
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_nur
dc.description.volume26
dc.identifier.doihttp://10.1177/0269881111408463
dc.description.ispublishedpub
dc.description.eprintid2663
rioxxterms.typearticle
qmu.authorChick, Jonathan
dc.description.statuspub
dc.description.number2


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