dc.contributor.author | Fyfe, Lorna | |
dc.contributor.author | Maingay, J P. | |
dc.contributor.author | Howie, S. E. M. | |
dc.date.accessioned | 2018-06-29T21:33:35Z | |
dc.date.available | 2018-06-29T21:33:35Z | |
dc.date.issued | 1993-01 | |
dc.identifier | ER3017 | |
dc.identifier.citation | Fyfe, L., Maingay, J. & Howie, S. (1993) Murine HIV p24 specific T lymphocyte activation by different antigen presenting cells: B lumphocytes from immunised mice present core protein to T-cells. Immunology Letters, 35(1), pp. 45-50. | |
dc.identifier.issn | 0165-2478 | |
dc.identifier.issn | 1879-0542 | |
dc.identifier.uri | https://doi.org/10.1016/0165-2478(93)90146-S | |
dc.identifier.uri | https://eresearch.qmu.ac.uk/handle/20.500.12289/3017 | |
dc.description.abstract | Mice were injected with three doses of baculovirus-produced recombinant HIV-1 p24 core protein in alum adjuvant. CD4 positive T lymphocytes from immunized animals proliferated in vitro in the presence of antigen and peritoneal macrophages (Mps) or splenic dendritic cells (DCs) from non-immunized mice as antigen presenting cells (APCs). DCs were approximately three times more efficient than Mps on a cell for cell basis. No synergy was observed between Mps and DCs in this system. B lymphocytes from immunized animals also presented p24 antigen to the specific T cells. Mps did synergize with B cells to enhance the level of T lymphocyte proliferation. This may have implications for the induction of specific immune responses to pathogens after administration of single protein vaccines. | |
dc.format.extent | 45-50 | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Immunology Letters | |
dc.title | Murine HIV p24 specific T lymphocyte activation by different antigen presenting cells: B lumphocytes from immunised mice present core protein to T-cells | |
dc.type | article | |
dcterms.accessRights | none | |
dc.description.faculty | sch_die | |
dc.description.volume | 35 | |
dc.description.ispublished | pub | |
dc.description.eprintid | 3017 | |
rioxxterms.type | article | |
qmu.author | Fyfe, Lorna | |
dc.description.status | pub | |
dc.description.number | 1 | |