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dc.contributor.authorFyfe, Lorna
dc.contributor.authorMaingay, J P.
dc.contributor.authorHowie, S. E. M.
dc.date.accessioned2018-06-29T21:33:35Z
dc.date.available2018-06-29T21:33:35Z
dc.date.issued1993-01
dc.identifierER3017
dc.identifier.citationFyfe, L., Maingay, J. & Howie, S. (1993) Murine HIV p24 specific T lymphocyte activation by different antigen presenting cells: B lumphocytes from immunised mice present core protein to T-cells, Immunology Letters, vol. 35, , pp. 45-50,
dc.identifier.issn0165-2478, ESSN 1879-0542
dc.identifier.urihttp://dx.doi.org/10.1016/0165-2478(93)90146-S
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/3017
dc.description.abstractMice were injected with three doses of baculovirus-produced recombinant HIV-1 p24 core protein in alum adjuvant. CD4 positive T lymphocytes from immunized animals proliferated in vitro in the presence of antigen and peritoneal macrophages (Mps) or splenic dendritic cells (DCs) from non-immunized mice as antigen presenting cells (APCs). DCs were approximately three times more efficient than Mps on a cell for cell basis. No synergy was observed between Mps and DCs in this system. B lymphocytes from immunized animals also presented p24 antigen to the specific T cells. Mps did synergize with B cells to enhance the level of T lymphocyte proliferation. This may have implications for the induction of specific immune responses to pathogens after administration of single protein vaccines.
dc.format.extent45-50
dc.publisherElsevier
dc.relation.ispartofImmunology Letters
dc.titleMurine HIV p24 specific T lymphocyte activation by different antigen presenting cells: B lumphocytes from immunised mice present core protein to T-cells
dc.typearticle
dcterms.accessRightsnone
dc.description.facultysch_die
dc.description.volume35
dc.description.ispublishedpub
dc.description.eprintid3017
rioxxterms.typearticle
qmu.authorFyfe, Lorna
dc.description.statuspub
dc.description.number1


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