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dc.contributor.authorTsang, Catherine
dc.contributor.authorSmail, Nacer Foudil
dc.contributor.authorAlmoosawi, Suzana
dc.contributor.authorDavidson, Isobel
dc.contributor.authorAl-Dujaili, Emad A. S.
dc.date.accessioned2018-06-29T21:33:44Z
dc.date.available2018-06-29T21:33:44Z
dc.date.issued2012-08
dc.identifierER3109
dc.identifier.citationTsang, C., Smail, N., Almoosawi, S., Davidson, I. & Al-Dujaili, E. (2012) Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers, Journal of Nutritional Science, vol. 1, , ,
dc.identifier.issn2048-6790
dc.identifier.urihttp://dx.doi.org/10.1017/jns.2012.10
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/3109
dc.description.abstractPomegranate juice (PJ; also known as pomegreat pure juice) provides a rich and varied source of polyphenolic compounds that may offer cardioprotective, anti-atherogenic and antihypertensive effects. The aim of this study was to investigate the effect of PJ consumption on glucocorticoids levels, blood pressure (BP) and insulin resistance in volunteers at high CVD risk. Subjects (twelve males and sixteen females) participated in a randomised, placebo-controlled cross-over study (BMI: 2677 (sd 336) kg/m2; mean age: 504 (sd 61) years). Volunteers were assessed at baseline, and at weeks 2 and 4 for anthropometry, BP and pulse wave velocity. Cortisol and cortisone levels in urine and saliva were determined by specific ELISA methods, and the cortisol/cortisone ratio was calculated. Fasting blood samples were obtained to assess plasma lipids, glucose, insulin and insulin resistance (homeostasis model assessment of insulin resistance). Volunteers consumed 500 ml of PJ or 500 ml of a placebo drink containing a similar amount of energy. Cortisol urinary output was reduced but not significant. However, cortisol/cortisone ratios in urine (P = 0009) and saliva (P = 0024) were significantly decreased. Systolic BP decreased from 1364 (sd 63) to 1289 (sd 51) mmHg (P = 0034), and diastolic BP from 803 (sd 429) to 755 (sd 517) mmHg (P = 0031) after 4 weeks of fruit juice consumption. Pulse wave velocity decreased from 75 (sd 086) to 744 (sd 094) m/s (P = 0035). There was also a significant reduction in fasting plasma insulin from 936 (sd 58) to 753 (sd 412) mIU/l (P = 0025) and of homeostasis model assessment of insulin resistance (from 2216 (sd 143) to 182 (sd 112), P = 0028). No significant changes were seen in the placebo arm of the study. These results suggest that PJ consumption can alleviate key cardiovascular risk factors in overweight and obese subjects that might be due to a reduction in both systolic and diastolic BP, possibly through the inhibition of 11_-hydroxysteroid dehydrogenase type 1 enzyme activity as evidenced by the reduction in the cortisol/cortisone ratio. The reduction in insulin resistance might have therapeutic benefits for patients with non-insulin-dependent diabetes, obesity and the metabolic syndrome.
dc.relation.ispartofJournal of Nutritional Science
dc.subjectPomegranate juice
dc.subjectBlood pressure
dc.subjectGlucocorticoids
dc.subjectObesity
dc.subject11_-Hydroxysteroid dehydrogenase
dc.subjectHomeostasis model assessment of insulin resistance
dc.titleIntake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers
dc.typearticle
dcterms.accessRightspublic
dc.description.facultysch_die
dc.description.volume1
dc.identifier.doihttp://doi:10.1017/jns.2012.10
dc.description.ispublishedpub
dc.description.eprintid3109
rioxxterms.typearticle
qmu.authorAl-Dujaili, Emad A. S.
qmu.authorTsang, Catherine
qmu.authorSmail, Nacer Foudil
qmu.authorAlmoosawi, Suzana
qmu.authorDavidson, Isobel
dc.description.statuspub


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