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dc.contributor.authorIbegbu, A. O.
dc.contributor.authorMullaney, I.
dc.contributor.authorFyfe, Lorna
dc.contributor.authorMcBean, Douglas
dc.date.accessioned2018-06-29T21:33:32Z
dc.date.available2018-06-29T21:33:32Z
dc.date.issued2012-12
dc.identifierER3122
dc.identifier.citationIbegbu, A., Mullaney, I., Fyfe, L. & McBean, D. (2012) Oxidative stress does not predispose neuronal cells to changes in G protein coupled (opioid) receptor gene expression in cortical B50 neurons in culture, International Journal of Human Genetics, vol. 12, , pp. 303-310,
dc.identifier.issn9723757
dc.identifier.urihttp://www.krepublishers.com/02-Journals/IJHG/IJHG-12-0-000-12-Web/IJHG-12-4-000-12-Abst-PDF/IJHG-12-4-303-12-495-Ibegbu-A-O/IJHG-12-4-303-12-495-Ibegbu-A-O-Tt.pdf
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/3122
dc.description.abstractOxidative stress adversely affects neuronal cells in which they may die when oxygen supply is reduced or eliminated and opioid receptor agonists elicit several central nervous system effects. The aim of this study was to evaluate the effect of oxidative stress on opioid receptor gene expression in cortical B50 cells. The cells were cultured in normoxia, hypoxia and treated with opioid agonists; DAMGO (_), DSLET () and ICI-199,441 () for 48 hours after 48 hours of initial culture at dose of 10_M, 50_M and 100_M. The level of mu opioid receptor mRNA was assessed using RT-PCR. The results show that oxidative stress induced changes in B50 cells in hypoxia while mu opioid mRNA levels showed no change. The results show that B50 cells are susceptible to damage by oxidative stress and opioid agonist treatments showed no change in the level of mu opioid receptor gene expression in B50 cells. Kamla-Raj 2012.
dc.format.extent303-310
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal of Human Genetics
dc.titleOxidative stress does not predispose neuronal cells to changes in G protein coupled (opioid) receptor gene expression in cortical B50 neurons in culture
dc.typearticle
dcterms.accessRightspublic
dc.description.facultysch_die
dc.description.volume12
dc.description.ispublishedpub
dc.description.eprintid3122
rioxxterms.typearticle
qmu.authorMcBean, Douglas
qmu.authorFyfe, Lorna
dc.description.statuspub
dc.description.number4


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