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dc.contributor.authorWhite, Lois
dc.contributor.authorMerrick, V. M.
dc.contributor.authorBannerman, Elaine
dc.contributor.authorRussell, R. K.
dc.contributor.authorBasude, D.
dc.contributor.authorHenderson, P.
dc.contributor.authorWilson, D. C.
dc.contributor.authorGillett, P. M.
dc.date.accessioned2018-06-29T21:34:03Z
dc.date.available2018-06-29T21:34:03Z
dc.date.issued2013-10
dc.identifierER3280
dc.identifier.citationWhite, L., Merrick, V., Bannerman, E., Russell, R., Basude, D., Henderson, P., Wilson, D. & Gillett, P. (2013) The rising incidence of celiac disease in Scotland, PEDIATRICS, vol. 132, , pp. e924-e931,
dc.identifier.issn0031-4005, ESSN: 1098-4275
dc.identifier.urihttps://doi.org/10.1542/peds.2013-0932
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/3280
dc.description.abstractBackground and objectives: Although the incidence of pediatric celiac disease (CD) is increasing globally, it is uncertain whether this is attributed to improved case ascertainment or signifies a true rise. We aimed to identify all incident cases of childhood CD in southeast Scotland over the period 1990 to 2009 to assess trends in totalincidence and cases diagnosed as a result of (1) a classic presentation, (2) a nonclassic presentation, or (3) targeted screening. Methods: Twenty-year retrospective cohortstudy of case notes, pathology databases, endoscopy, and patient records for all children (<16 years of age) diagnosed with CD on biopsy in southeast Scotland (at-riskpopulation of 225 000-233 000). Data were age-gender standardized and Poisson regression models used to calculate changes in incidence over time. Results: A total of 266 children were diagnosed from 1990 to 2009 with an increase in incidence from 1.8/100 000(95% confidence interval [CI] 1.1-2.7) to 11.7/100 000 (95% CI 9.8-13.9) between the epochs 1990 to 1994 and 2005 to 2009, respectively (P < .0001). The incidence of nonclassic presentation (children with a monosymptomatic presentation and those with extraintestinal symptoms) and actively screened cases increased by 1566% (P < .05) and 1170% (P < .001) from 1990 to 1999 to 2000 to 2009, respectively. However, a rise in the incidence of Oslo classic cases from 1.51/100 000 (95% CI 0.91-2.38) in 1990 to 1994 to 5.22/100 000 (95% CI 3.98-6.75) in 2005 to 2009 (P < .01) remained evident. Conclusions: The incidence of pediatric CD increased 6.4-fold over the 20 years. This study demonstrates that this rise is significant for classic CD, indicating a true rise in the incidence of pediatric CD. 2013 by the American Academy of Pediatrics.
dc.format.extente924-e931
dc.relation.ispartofPEDIATRICS
dc.titleThe rising incidence of celiac disease in Scotland
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_die
dc.description.volume132
dc.identifier.doihttp://10.1542/peds.2013-0932
dc.description.ispublishedpub
dc.description.eprintid3280
rioxxterms.typearticle
qmu.authorBannerman, Elaine
qmu.authorWhite, Lois
dc.description.statuspub
dc.description.number4


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