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dc.contributor.authorPettigrew, K. A.
dc.contributor.authorFajutrao Valles, S.
dc.contributor.authorMoll, K.
dc.contributor.authorNorthstone, K.
dc.contributor.authorRing, S.
dc.contributor.authorPennell, C.
dc.contributor.authorWang, C.
dc.contributor.authorLeavett, R.
dc.contributor.authorHayiou-Thomas, M. E.
dc.contributor.authorThompson, P.
dc.contributor.authorSimpson, N. H.
dc.contributor.authorFisher, S. E.
dc.contributor.authorWhitehouse, A. J. O.
dc.contributor.authorSnowling, M. J.
dc.contributor.authorNewbury, D. F.
dc.contributor.authorParacchini, S.
dc.contributor.authorClark, Ann
dc.contributor.authorWatson, Jocelynne
dc.date.accessioned2018-06-29T15:53:51Z
dc.date.available2018-06-29T15:53:51Z
dc.date.issued2015-04-01
dc.identifierER3906
dc.identifier.citationPettigrew, K., Fajutrao Valles, S., Moll, K., Northstone, K., Ring, S., Pennell, C., Wang, C., Leavett, R., Hayiou-Thomas, M., Thompson, P., Simpson, N., Fisher, S., Whitehouse, A., Snowling, M., Newbury, D., Paracchini, S., Clark, A. & Watson, J. (2015) Lack of replication for the myosin-18B association with mathematical ability in independent cohorts, Genes, Brain and Behavior, vol. 14, , pp. 369-376,
dc.identifier.issn16011848
dc.identifier.urihttp://dx.doi.org/10.1111/gbb.12213
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/3906
dc.description.abstractTwin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability. 2015 The Authors.
dc.format.extent369-376
dc.relation.ispartofGenes, Brain and Behavior
dc.titleLack of replication for the myosin-18B association with mathematical ability in independent cohorts
dc.typearticle
dcterms.accessRightspublic
dc.description.facultycasl
dc.description.volume14
dc.identifier.doihttp://doi:10.1111/gbb.12213
dc.description.ispublishedpub
dc.description.eprintid3906
rioxxterms.typearticle
qmu.authorWatson, Jocelynne
qmu.authorClark, Ann
qmu.centreCASL
dc.description.statuspub
dc.description.number4


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