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dc.contributor.authorHill, Gareth
dc.contributor.authorMeikle, Dora
dc.date.accessioned2018-06-29T21:52:24Z
dc.date.available2018-06-29T21:52:24Z
dc.date.issued2016-02
dc.identifierER4005
dc.identifier.citationHill, G. & Meikle, D. (2016) The role of total body irradiation (TBI) as a conditioning regime for paediatric acute lymphoblastic leukaemia: A discussion of the evidence, Radiography, vol. 22, , pp. e11-e15,
dc.identifier.issn10788174
dc.identifier.urihttp://dx.doi.org/10.1016/j.radi.2015.04.003
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4005
dc.description.abstractAim: The long term effects of TBI with children can be adverse and has resulted in a debate as to whether chemotherapy only based condition regimes could be used as an alternatives. The aim of this article is to critically evaluate the literature relating to the role of TBI as a conditioning regime in ALL in children, and if there are any alternatives to current practices or future developments. Method: Key databases were searched for terms: conditioning regimes, transplantation, TBI, whole body radiation, systemic irradiation, stem cell transplantation, hematopoietic stem cell, and transplant conditioning. Results: Thirteen research articles from a variety of publications and two guidance documents from several sources were uncovered for critical discussion. Discussion/conclusion: There is little evidence for chemotherapy only regimes in paediatric ALL, but the practice continues. Modulating doses to improve homogeneity and use of IGRT could hold a future solution to reducing long-term toxicity and maintain the efficacy of irradiation. 2015 The College of Radiographers.
dc.format.extente11-e15
dc.publisherWB Saunders Ltd
dc.relation.ispartofRadiography
dc.titleThe role of total body irradiation (TBI) as a conditioning regime for paediatric acute lymphoblastic leukaemia: A discussion of the evidence
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_rad
dc.description.volume22
dc.identifier.doihttp://doi:10.1016/j.radi.2015.04.003
dc.description.ispublishedpub
dc.description.eprintid4005
rioxxterms.typearticle
qmu.authorMeikle, Dora
qmu.authorHill, Gareth
qmu.centreCentre for Person-centred Practise Research
dc.description.statuspub
dc.description.number1


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