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dc.contributor.authorTehan, P. E.
dc.contributor.authorSantos, Derek
dc.contributor.authorChuter, V. H.
dc.date.accessioned2018-06-29T21:48:55Z
dc.date.available2018-06-29T21:48:55Z
dc.date.issued2016-05-10
dc.identifierER4356
dc.identifier.citationTehan, P., Santos, D. & Chuter, V. (2016) A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease, Vascular Medicine, vol. 21, , pp. 382-389,
dc.identifier.issn1358-863X
dc.identifier.urihttp://doi.org/10.1177/1358863X16645854
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4356
dc.description.abstractThe toe-brachial index (TBI) is used as an adjunct to the ankle-brachial index (ABI) for non-invasive lower limb vascular screening. With increasing evidence suggesting limitations of the ABI for diagnosis of vascular complications, particularly in specific populations including diabetes cohorts, the TBI is being used more widely. The aim of this review was to determine the sensitivity and specificity of the TBI for detecting peripheral artery disease (PAD) in populations at risk of this disease. A database search was conducted to identify current work relating to the sensitivity and specificity of toe-brachial indices up to July 2015. Only studies using valid diagnostic imaging as a reference standard were included. The QUADAS-2 tool was used to critically appraise included articles. Seven studies met the inclusion criteria. Sensitivity of the TBI for PAD was reported in all seven studies and ranged from 45% to 100%; specificity was reported by five studies only and ranged from 16% to 100%. In conclusion, this review suggests that the TBI has variable diagnostic accuracy for the presence of PAD in specific populations at risk of developing the disease. There was a notable lack of large-scale diagnostic accuracy studies determining the diagnostic accuracy of the TBI in detecting PAD in different at-risk cohorts. However, standardised normal values need to be established for the TBI to conclusively determine the diagnostic accuracy of this test.
dc.format.extent382-389
dc.publisherSAGE
dc.relation.ispartofVascular Medicine
dc.titleA systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_pod
dc.description.volume21
dc.identifier.doihttp://doi:10.1177/1358863X16645854
dc.description.ispublishedpub
dc.description.eprintid4356
rioxxterms.typearticle
refterms.dateAccepted2016-03-17
qmu.authorSantos, Derek
qmu.centreCentre for Health, Activity and Rehabilitation Research
dc.description.statuspub
dc.description.number4


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