Show simple item record

dc.contributor.authorGow, Iain F.
dc.contributor.authorMitchell, Evelyn
dc.contributor.authorWait, Martin
dc.date.accessioned2018-06-29T21:34:11Z
dc.date.available2018-06-29T21:34:11Z
dc.date.issued2003-05-15
dc.identifierER4388
dc.identifier.citationGow, I., Mitchell, E. & Wait, M. (2003) Adrenergic receptors in the bovine mammary artery., Biochemical pharmacology, vol. 65, , pp. 1747-1753,
dc.identifier.issnJun-52
dc.identifier.urihttp://dx.doi.org/10.1016/S0006-2952(03)00112-6
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4388
dc.description.abstractThe response of isolated preparations of bovine mammary artery was investigated, with the aim of characterising further the adrenergic receptor subtypes present. Noradrenaline (NA) and the alpha(1) agonist phenylephrine gave sigmoidal dose-response curves with pEC(50) values of 5.97+/-0.07 (N=34) and 6.21+/-0.32 (N=8), respectively. Stimulation of alpha(2) receptors with UK 14,304 produced a weak response with pEC(50) of 6.78+/-0.38 (N=7), and maximal contraction of 17.8+/-9.9% relative to NA. A61603, an alpha(1A) agonist, gave a curve parallel to NA, but shifted to the left (pEC(50) of 6.98+/-0.19 (N=5)); this drug had an increased potency of 10-fold relative to NA, and 4-fold relative to phenylephrine. Schild analysis of curves obtained with the alpha(1) antagonist prazosin gave a pA(2) of 8.70+/-0.47 (N=6-9), whereas the alpha(2) antagonist yohimbine resulted in a pA(2) of 7.65+/-0.16 (N=4). The alpha(1A) receptor antagonists WB4101 and 5-methylurapidil gave pA(2) values of 9.39+/-0.69 (N=4) and 7.72+/-0.02 (N=2-3), respectively. The irreversible alpha(1B) inhibitor CEC reduced the pEC(50) from 5.39+/-0.12 to 4.31+/-0.18 (N=7) only at the highest dose used, and high doses of the alpha(1D) antagonist BMY 7378 produced a shift to the right at giving a pA(2) of 7.37+/-0.08 (N=3). These results suggest major involvement of the alpha(1B) adrenergic receptor subtype in contraction of the bovine mammary artery, which is similar to the human internal mammary artery.
dc.description.abstractPaper adds to the growing body of evidence that children can acquire phonological systems before they are able to master the phonetic skills needed to convey the contrasts in that system
dc.format.extent1747-1753
dc.publisherScience Direct
dc.relation.ispartofBiochemical pharmacology
dc.titleAdrenergic receptors in the bovine mammary artery.
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_die
dc.description.volume65
dc.identifier.doihttp://10.1016/S0006-2952(03)00112-6
dc.description.ispublishedpub
dc.description.eprintid4388
rioxxterms.typearticle
refterms.dateAccepted2003-02-13
dc.description.statuspub
dc.description.number10


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record