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    Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I.

    Date
    2000-05-30
    Author
    Gow, Iain F.
    Metadata
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    Citation
    Gow, I. (2000) Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I., Experimental physiology, vol. 85, , pp. 275-279,
    Abstract
    Isolated mammary arteries from ruminants were used in a conventional organ bath system. Acetylcholine relaxed bovine but not ovine mammary arteries; both types responded to sodium nitroprusside. Noradrenaline (NA) caused a dose-dependent increase in generated tension. An analogue of insulin-like growth factor I (long R3-IGF-I) caused a rightward shift in the NA response curve in bovine vessels with intact endothelium (P < 0.02), and also in sheep arteries (P < 0.01). In bovine vessels, this effect was abolished when the endothelium was removed. The effect of long R3-IGF-I in bovine vessels was abolished by N -nitro-L-arginine methyl ester (L-NAME) an inhibitor of nitric oxide synthase, suggesting the effect of IGF-I on mammary arteries in vitro requires NO generation.
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/4392
    Official URL
    http://onlinelibrary.wiley.com/doi/10.1111/j.1469-445X.2000.01973.x/full
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    • Dietetics, Nutrition and Biological Sciences

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