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dc.contributor.authorGow, Iain F.
dc.date.accessioned2018-07-20T09:01:53Z
dc.date.available2018-07-20T09:01:53Z
dc.date.issued2000-05-30
dc.identifier.citationGow, I. (2000) Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I., Experimental physiology, vol. 85, , pp. 275-279,
dc.identifier.issn0958-0670
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4392
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1469-445X.2000.01973.x/full
dc.description.abstractIsolated mammary arteries from ruminants were used in a conventional organ bath system. Acetylcholine relaxed bovine but not ovine mammary arteries; both types responded to sodium nitroprusside. Noradrenaline (NA) caused a dose-dependent increase in generated tension. An analogue of insulin-like growth factor I (long R3-IGF-I) caused a rightward shift in the NA response curve in bovine vessels with intact endothelium (P < 0.02), and also in sheep arteries (P < 0.01). In bovine vessels, this effect was abolished when the endothelium was removed. The effect of long R3-IGF-I in bovine vessels was abolished by N -nitro-L-arginine methyl ester (L-NAME) an inhibitor of nitric oxide synthase, suggesting the effect of IGF-I on mammary arteries in vitro requires NO generation.
dc.format.extent275-279
dc.publisherThe Physiological Society
dc.relation.ispartofExperimental physiology
dc.titleResponse of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I.
dc.typearticle
dcterms.accessRightspublic
dc.description.facultyNO DIVISION
dc.description.volume85
dc.identifier.doi10.1111/j.1469-445X.2000.01973.x
dc.description.ispublishedpub
dc.description.eprintid4392
rioxxterms.typearticle
rioxxterms.publicationdate30/05/2000
refterms.dateAccepted2000-02-22
qmu.authorGow, Iain F.
dc.description.statuspub
dc.description.number3


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