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dc.contributor.authorGow, Iain F.
dc.contributor.authorDockrell, M.
dc.contributor.authorEdwards, C. R.
dc.contributor.authorElder, A.
dc.contributor.authorGrieve, J.
dc.contributor.authorKane, G.
dc.contributor.authorPadfield, P. L.
dc.contributor.authorWaugh, C. J.
dc.contributor.authorWilliams, B. C.
dc.date.accessioned2018-06-29T21:33:23Z
dc.date.available2018-06-29T21:33:23Z
dc.date.issued1992-07-31
dc.identifierER4403
dc.identifier.citationGow, I., Dockrell, M., Edwards, C., Elder, A., Grieve, J., Kane, G., Padfield, P., Waugh, C. & Williams, B. (1992) The sensitivity of human blood platelets to the aggregating agent ADP during different dietary sodium intakes in healthy men., European journal of clinical pharmacology, vol. 43, , pp. 635-8,
dc.identifier.issn0031-6970
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4403
dc.description.abstractWe have investigated the effect of varying sodium intake on the renin-angiotensin system, ADP-induced platelet aggregation in vitro, and blood 5-HT concentrations in 9 male volunteers. Systolic blood pressure was slightly reduced during a low sodium diet, whereas the diastolic pressure remained unchanged. Plasma renin activity and aldosterone concentration both fell significantly when sodium intake was increased; plasma angiotensin II concentration also fell, but not significantly. There was a significant fall in haematocrit after an increased sodium intake, but there was no change in the whole-blood platelet count after correcting for this. There were no significant changes in either total (i.e. PRP) or platelet 5-HT concentrations. The extent of platelet aggregation induced by 5 and 20 mumol.l-1 of ADP increased significantly when dietary sodium intake was increased. When compared with low or normal sodium intakes, lower concentrations of ADP were required to produce 50% of maximum aggregation after a high sodium intake. The 5-HT2 receptor antagonist ketanserin (1 mumol.l-1 in vitro) reduced the extent of aggregation induced by 5 mumol.l-1 ADP after the volunteers had taken a high sodium diet, whereas the angiotensin II receptor antagonist saralasin (1 nmol.l-1) increased the rate of aggregation after the low sodium diet. Thus, during a high sodium intake, human platelets become more sensitive to the aggregating agent ADP. It is possible that this effect is mediated via platelet 5-HT2 receptors, since ketanserin abolished the increase in salt-induced aggregation seen with 5 mumol.l-1 ADP.
dc.format.extent635-8
dc.relation.ispartofEuropean journal of clinical pharmacology
dc.titleThe sensitivity of human blood platelets to the aggregating agent ADP during different dietary sodium intakes in healthy men.
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_die
dc.description.volume43
dc.description.ispublishedpub
dc.description.eprintid4403
rioxxterms.typearticle
refterms.dateAccepted1992-06-30
dc.description.statuspub
dc.description.number6


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