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dc.contributorConroy, K. P.
dc.contributorDavidson, I.
dc.contributorWarnock, Mary
dc.contributor.authorConroy, Kylie
dc.contributor.authorDavidson, Isobel
dc.contributor.authorWarnock, Mary
dc.date.accessioned2018-06-29T21:33:05Z
dc.date.available2018-06-29T21:33:05Z
dc.date.issued2011-08-22
dc.identifierER4603
dc.identifier.citationConroy, K., Davidson, I. & Warnock, M. (2011) Pathogenic obesity and nutraceuticals, Proceedings of the Nutrition Society, vol. 70, , pp. 426-438,
dc.identifier.issn0029-6651
dc.identifier.urihttps://doi.org/10.1017/S0029665111001662
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4603
dc.description.abstractOver a decade of intense research in the field of obesity has led to the knowledge that chronic, excessive adipose tissue expansion leads to an increase in the risk for CVD, type 2 diabetes mellitus and cancer. This is primarily thought to stem from the low-grade, systemic inflammatory response syndrome that characterises adipose tissue in obesity, and this itself is thought to arise from the complex interplay of factors including metabolic endotoxaemia, increased plasma NEFA, hypertrophic adipocytes and localised hypoxia. Plasma concentrations of vitamins and antioxidants are lower in obese individuals than in the non-obese, which is hypothesised to negatively affect the development of inflammation and disease in obesity. This paper provides a review of the current literature investigating the potential of nutraceuticals to ameliorate the development of oxidative stress and inflammation in obesity, thereby limiting the onset of obesity complications. Research has found nutraceuticals able to positively modulate the activity of adipocyte cell lines and further positive effects have been found in other aspects of pathogenic obesity. While their ability to affect weight loss is still controversial, it is clear that they have a great potential to reverse the development of overweight and obesity-related comorbidities; this, however, still requires much research especially that utilising well-structured randomised controlled trials.
dc.format.extent426-438
dc.publisherCambridge University Press
dc.relation.ispartofProceedings of the Nutrition Society
dc.titlePathogenic obesity and nutraceuticals
dc.typearticle
dcterms.accessRightspublic
dc.description.facultysch_die
dc.description.volume70
dc.identifier.doihttp://10.1017/S0029665111001662
dc.description.ispublishedpub
dc.description.eprintid4603
rioxxterms.typearticle
refterms.dateAccepted2011-02-16
qmu.authorWarnock, Mary
qmu.authorConroy, Kylie
qmu.authorDavidson, Isobel
qmu.centreCentre for Health, Activity and Rehabilitation Research
dc.description.statuspub
dc.description.number4


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