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dc.contributor.authorMoss-Morris, Rona
dc.contributor.authorMercer, Tom
dc.contributor.authorWhite, Claire
dc.contributor.authorvan der Linden, Marietta
dc.contributor.authorThomas, Sarah
dc.contributor.authorHarrison, Anthony
dc.contributor.authorSafari, Reza
dc.contributor.authorNorton, Sam
dc.date.accessioned2018-06-29T21:44:37Z
dc.date.available2018-06-29T21:44:37Z
dc.date.issued2016-08-22
dc.identifierER4615
dc.identifier.citationMoss-Morris, R., Mercer, T., White, C., van der Linden, M., Thomas, S., Harrison, A., Safari, R. & Norton, S. (3916) Efficacy of targeted versus non-targeted exercise and behavioural interventions on fatigue in multiple sclerosis: systematic review and meta-analysis, PROSPERO.
dc.identifier.urihttp://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016036671
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/4615
dc.descriptionConflicts of interest Two members of the review team, Professor Rona Moss-Morris and Dr Sarah Thomas have published randomised controlled trials of behavioural interventions for fatigue in multiple sclerosis which meet the inclusion criteria of the current review. Preliminary searches, formal screening of search results against eligibility criteria, data extraction, risk of bias assessment and data analysis will be conducted independently of these individuals.
dc.description.abstractReview question(s) The specific objectives are to: (1) Provide a narrative synthesis of all the interventions, including a summary of the nature of the intervention using the Template for intervention Description and Replication (TiDieR), and assessment of study quality (risk of bias), alongside the standardised intervention effect sizes. As a detailed synthesis already includes studies evaluating interventions specifically targeting MS fatigue (ref: CRD42016033763), the narrative synthesis will focus on studies evaluating interventions that (a) do not specifically target fatigue, or (b) measured fatigue as a secondary outcome. (2) Conduct (pair-wise) meta-analyses to pool effect sizes across intervention types (exercise, behavioural, mixed) and estimate statistical heterogeneity. (3) Directly compare specific types of targeted versus non-targeted exercise, behavioural and combined interventions on fatigue in multiple sclerosis, using network meta-analyses. (4) Conduct exploratory moderator and sensitivity analyses to explore how treatment effects vary according to health care professional (HCP) contact, type of MS, and study quality (i.e. risk of bias).
dc.publisherPROSPERO
dc.relation.ispartofPROSPERO
dc.titleEfficacy of targeted versus non-targeted exercise and behavioural interventions on fatigue in multiple sclerosis: systematic review and meta-analysis
dc.typemonograph
dcterms.accessRightspublic
dc.description.facultysch_phy
dc.description.ispublishedpub
dc.description.eprintid4615
rioxxterms.typemonograph
refterms.dateFCA2016-11-21
refterms.dateFCD2016-11-21
qmu.authorvan der Linden, Marietta
qmu.authorMercer, Tom
qmu.centreCentre for Health, Activity and Rehabilitation Research
dc.description.statuspub


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