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    Development of prognostic model for fistula maturation in patients with advanced renal failure

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    Published Version - Available under License Creative Commons Attribution. (707.3Kb)
    Date
    2018-03-07
    Author
    Siddiqui, Muhammad A.
    Ashraff, Suhel
    Santos, Derek
    Rush, Robert
    Carline, Tom
    Raza, Zahid
    Metadata
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    Citation
    Siddiqui, M., Ashraff, S., Santos, D., Rush, R., Carline, T. & Raza, Z. (2018) Development of prognostic model for fistula maturation in patients with advanced renal failure, Renal Replacement Therapy, vol. 4, , ,
    Abstract
    Background: This study aimed to explore the role of patient's characteristic and haematological factors as predictive on the maturation of arteriovenous fistulae in patients who underwent vascular access surgery at the Royal Infirmary of Edinburgh. Methods: Retrospective data from 300 patients who had undergone fistula creation between February 2007 and October 2010 was examined. A predictive logistic regression model was developed using the backward stepwise procedure. Model performance, discrimination and calibration, was assessed using the receiver operating characteristics (ROC) curve and Hosmer and Lemeshow goodness of fit test. Results: Three variables were identified which independently influenced fistula maturation. Males were twice as likely to undergo fistula maturation, compared to that of females (odds ratio (OR) 0.514; 95% confidence interval (CI) 0.308-0.857), patients with no evidence of peripheral vascular disease (PVD) were three times more likely to mature their fistula (OR 3.140; 95% CI 1.596-6.177) and a pre-operative vein diameter > 2.5 mm resulted in a fivefold increase in fistula maturation compared to a vein size less than 2.5 mm (OR 4.532; 95% CI 2.063-9.958). The model for fistula maturation had fair discrimination as indicated by the area under the ROC curve (0.68; 95% CI 0.615-0. 738) but good calibration indicated by Hosmer and Lemeshow test (p = 0.79). Conclusion: Gender, PVD and vein size are independent predictors of arteriovenous fistula maturation. The clinical utility of these risk equation in the maturation of arteriovenous fistulae requires further validation in the newly treated patients.
    Official URL
    https://doi.org/10.1186/s41100-018-0153-z
    URI
    https://eresearch.qmu.ac.uk/handle/20.500.12289/5237
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