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dc.contributor.authorFarhat, Grace
dc.date.accessioned2018-07-27T15:40:50Z
dc.date.available2018-07-27T15:40:50Z
dc.date.issued2014
dc.identifierET1819
dc.identifier.citationFarhat, G. (2014) Effect of polyphenol-rich dark chocolate on anthropometric, nutritional, biochemical and physiological markers in normal weight and overweight adults, no. 334.
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/7371
dc.description.abstractPolyphenols are phytochemicals widely available in plants. Dark chocolate (DC) is a high source of polyphenols, particularly flavanols. Studies previously reported a beneficial effect of polyphenol-rich dark chocolate (PRDC) on insulin sensitivity and oxidative stress, while its effects on blood pressure, serum lipid levels and inflammation remain unclear. In addition, a research area regarding the effect of PRDC on body weight control emerged recently. Two investigations were carried out. Study I (61 participants) looked at the effect of PRDC on insulin sensitivity in normal weight and overweight adults, while Study II (14 participants) investigated the effect of PRDC on body weight in overweight individuals. Volunteers received 20g of either PRDC (500mg of polyphenols) or placebo DC (low in polyphenols) daily for 4 weeks (Study I) or 12 weeks (Study II). Anthropometric measures and blood, saliva and urine samples were taken. Results showed that 4 weeks of PRDC supplementation decreased insulin levels (p<0.001) and HOMA-IR (p=0.003), and increased QUICKI (p<0.001), but had no significant impact on glucose levels (p=0.16). However, participants administered placebo DC showed an increase in insulin (p=0.014), HOMA-IR (p=0.003), TG (p= 0.008), glucose (p=0.041) and BMI (p=0.007) levels and a decrease in QUICKI (p=0.013). No significant changes in blood pressure, other serum lipid levels or glucocorticoid hormones were noted in both groups. In study II, there was an increase in BMI in the whole study population (p=0.046) with no significant difference between groups. Results indicate a potential implication of PRDC in the prevention of risk factors for cardiovascular diseases. Findings also highlight the detrimental effects of placebo DC, and propose the analysis of polyphenol content of different DC brands in the market. The increase in BMI and other markers only in the placebo group after four weeks, suggests that PRDC may counteract the adverse effects of fat and energy in the diet. However, the increase in BMI in both groups after 12 weeks implies further investigations to test the counteracting effect of PRDC over the long term.
dc.format.extent334
dc.publisherQueen Margaret University, Edinburgh
dc.subjectPolyphenol-Rich Dark Chocolate
dc.subjectPlacebo Dc
dc.subjectInsulin Sensitivity
dc.subjectHoma-Ir
dc.subjectQuicki
dc.subjectLdl Oxidation
dc.subjectGlucose
dc.subjectTg
dc.subjectBmi.
dc.titleEffect of polyphenol-rich dark chocolate on anthropometric, nutritional, biochemical and physiological markers in normal weight and overweight adults
dc.typeThesis
dcterms.accessRightspublic
dc.description.facultysub_dnbs
dc.description.ispublishedunpub
dc.description.eprintid1819_etheses
rioxxterms.typeThesis
dc.description.statusunpub
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhD Doctor of Philosophy


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