Show simple item record

dc.contributor.authorGrant, L.
dc.contributor.authorMcBean, Douglas
dc.contributor.authorFyfe, Lorna
dc.contributor.authorWarnock, Mary
dc.date.accessioned2018-06-29T21:32:57Z
dc.date.available2018-06-29T21:32:57Z
dc.date.issued2009
dc.identifierER795
dc.identifier.citationGrant, L., McBean, D., Fyfe, L. & Warnock, M. (2009) Effects of Harpagophytum procumbens (Devils'Claw) on the Cyclooxygenase and Lipoxygenase Pathways of the Arachidonic Acid Cascade, Recent Progress in Medicinal Plants, vol. 24, , pp. 203-219,
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/795
dc.description.abstractThe study was carried out to elucidate the mechanism(s) of action of the anti-inflammatory and analgesic properties of Harpagophytum procumbens (Hp; Devil's Claw). The in vitro effects of two preparations of Hp on the arachidonic acid cascade were monitored using whole blood aggregation and enzyme immunoassays for prostaglandin E2 (PGE2) and leukotriene B4(LTB4), indices of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). Neither Hp preparation significantly altered plasma levels of PGE2 or serum levels of LTB4. Both preparations of Hp had no effect on the COX or 5-LOX arms of the AA cascade, as determined by whole blood aggregation and EIAs for PGE2 and LTB4. This would indicate that Hp does not share the same mechanism of action as standard nonsteroidal anti-inflammatory drugs and suggests that another mechanism is responsible for the anti-inflammatory and analgesic effects of Hp that have been observed in numerous animal and human clinical trials.
dc.description.abstractOur Research Report for 2000-2002 reflects an outstanding level of achievement throughout the institution and demonstrates once again our high level of commitment to strategic and applied research particularly in areas that enhance the quality of life.
dc.format.extent203-219
dc.relation.ispartofRecent Progress in Medicinal Plants
dc.titleEffects of Harpagophytum procumbens (Devils'Claw) on the Cyclooxygenase and Lipoxygenase Pathways of the Arachidonic Acid Cascade
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_die
dc.description.volume24
dc.description.ispublishedpub
dc.description.eprintid795
rioxxterms.typearticle
qmu.authorWarnock, Mary
qmu.authorMcBean, Douglas
qmu.authorFyfe, Lorna
dc.description.statuspub
dc.description.number11


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record