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dc.contributor.authorDonaldson, C. L.
dc.contributor.authorCarline, Tom
dc.contributor.authorBrown, D. M.
dc.contributor.authorGilmour, P. S.
dc.contributor.authorDonaldson, K.
dc.date.accessioned2018-06-29T21:48:28Z
dc.date.available2018-06-29T21:48:28Z
dc.date.issued2002
dc.identifierER833
dc.identifier.citationDonaldson, C., Carline, T., Brown, D., Gilmour, P. & Donaldson, K. (2002) Toenail Dust Particles: A Potential Inhalation Hazard to Podiatrists?, The Annals of Occupational Hygiene, vol. 46, , pp. 365-368,
dc.identifier.issnMar-78
dc.identifier.urihttp://is.gd/4X0gD
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/833
dc.description.abstractToenail dust collected from podiatrist's nail drills was examined for size, endotoxin content and ability to stimulate release of interleukin 8 (IL-8) from macrophages and lung epithelial cells in vitro. The size distribution revealed a large number of particles in the size ranges that would deposit in the nose, airways and lung periphery. Endotoxin was readily measurable in aqueous extracts of the nail particles and a soluble component of the nail dust particles was able to stimulate substantial release of IL-8 from epithelial cells. Suspensions of toenail particles were tested for ability to stimulate IL-8 release from monocyte-derived macrophages; treatment with polymyxin B to remove endotoxin had no effect. We conclude that podiatrists who routinely carry out nail drilling could be inhaling particles that can deposit throughout the respiratory tract, where they could contribute to inflammation by stimulating release of IL-8 from cells via the particles themselves and via endotoxin.
dc.format.extent365-368
dc.publisherOxford University Press
dc.relation.ispartofThe Annals of Occupational Hygiene
dc.subjectendotoxin
dc.subjectIL-8
dc.subjecttoenail dust
dc.titleToenail Dust Particles: A Potential Inhalation Hazard to Podiatrists?
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_pod
dc.description.referencetextAbramson C, Wilton J. (1985a) Inhalation of nail dust from onychomycotic toenails. Part I. Characterization of particles. J Am Podiatric Med Assoc; 75: 563-7. Abramson C, Wilton J. (1985b) Nail dust aerosols from onychomycotic toenails. Part II. Clinical and serologic aspects. J Am Podiatric Med Assoc; 75: 631-8. Brown DM, Donaldson K. (1996) Wool and grain dusts stimulate TNF secretion by alveolar macrophages in vitro. Occup Environ Med; 53: 387-93. Davies RR. (1984) Human nail dust in chiropodial practice: irritant, allergen and source of antibodies to Trichophyton rubrum. J R Soc Health; 104: 1-5. Davies RR, Ganderton MA, Savage MA. (1983) Human nail dust and precipitating antibodies to Trichophyton rubrum in chiropodists. Clin Allergy; 13: 309-15. Driscoll KE, Carter JM, Hassenbein DG, Howard B. (1997) Cytokines and particle-induced inflammatory cell recruitment. Environ Health Perspect; 105: 1159-64. Gatley M. (1991) Human nail dust: hazard to chiropodists or merely nuisance? J Soc Occup Med; 41: 121-5. Gilmour PS, Rahman I, Hayashi S, Hogg JC, Donaldson K, MacNee W. (2001) Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8. Am J Physiol Lung Cell Mol Physiol; 281: L598-606. Ning Y, Imrich A, Goldsmith CA, Qin G, Kobzik L. (2000) Alveolar macrophage cytokine production in response to air particles in vitro: role of endotoxin. J Toxicol Environ Health; 59A: 165-80. Pope CA, Dockery DW. (1999) Epidemiology of particle effects. In Holgate ST, Samet JM, Koren HS, Maynard RL, editors. Air pollution and health. San Diego, CA: Academic Press. pp. 673-705. Schlesinger RB, Bender JR, Dahl AR, Snipes MB, Ultman J. (1998) Deposition of inhaled toxicicants. In Massaro EJ, editor. Handbook of human toxicology. Boca Raton, FL: CRC Press. pp. 493-550. Streiter RM, Kunkel SL. (1997) Chemokines. In Crystal RG, West JB, editors. The lung. Scientific foundations. Philadelphia, PA: Lippincott Raven. pp. 155-79. Ward PE. (1995) Atopy and reaction to nail dust inhalation. Clin Podiatric Med Surg; 12: 275-8.
dc.description.volume46
dc.description.ispublishedpub
dc.description.eprintid833
rioxxterms.typearticle
qmu.authorCarline, Tom
dc.description.statuspub
dc.description.number1


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