The effects of curcumin supplementation on type 2 diabetes physiological and biochemical markers in healthy volunteers.
(2017) The effects of curcumin supplementation on type 2 diabetes physiological and biochemical markers in healthy volunteers., no. 57.
Background: Curcumin, a polyphenol found in the root vegetable turmeric, has demonstrated potent anti-inflammatory and anti-oxidant effects in several in vivo and in vitro studies. Recent research supports its therapeutic potential on various biochemical and physiological biomarkers of type two diabetes mellitus. However, much of this research remains in vitro and although results have been significantly constructive, more research is required into the efficacy of its therapeutic use. Aims and objectives: The aim of this study is to evaluate the effects of curcumin in a population of healthy individuals on important parameters of type two diabetes. The objective is to add to the accumulating research on curcumin supplementation and elucidate its efficacy in treatment of type two diabetes. Methodology: A randomised double-blind, placebo-control trial was conducted over a 3 week period. 14 eligible participants were randomly allocated either placebo or curcumin supplementation to be taken twice a day over 7 consecutive days. The parameters investigated were; blood pressure, arterial compliance (measured via pulse wave velocity and augmentation index), blood glucose response and cholesterol. Tests were carried out pre- and post-intervention. Analysis was carried out using independent and paired t-tests. Physical activity and nutrient intake records were also evaluated. Results: Baseline measurements were not statistically different between groups. Postprandial blood glucose area under the curve significantly decreased in the curcumin-treated group (P=0.02) from 169.29 +/-91.1 mM.min to 104.57+/- 55.4 mM.min. Diastolic blood pressure also significantly increased in the curcumin-treated group (P=0.04), from 74 +/-11.0 mmHg 80 +/-7.1mmHg and decreasing trends were seen in systolic and PWV. No significant changes were observed in the placebo-treated group. Conclusions: These results indicate that curcumin can improve blood glucose response in a healthy population. This is consistent with previous clinical trials. It is possible that these effects are transferable to diabetes patients and with accumulative research curcumin may become a beneficial preventative and mediation therapy. Key words: curcumin, blood glucose, pulse wave velocity, type 2 diabetes, cholesterol, augmentation index.