|dc.description.abstract||Background: Salvia Officinalis (sage) has been used for centuries as a medicinal plant. Recently, it has become the centre of research as a natural memory enhancer of particular interest for treatment of diseases such as Alzheimer's Disease. It is also known that it contains polyphenols which have strong antioxidant effects and can be used to present cardiovascular disease. However it is not known whether the effects of sage can have prolonged beneficial effects.
Aims/Objectives: The purpose of this study was to determine the effects of fresh sage tincture on cognitive function on university students aged 18-30 via the use of three cognitive tests, the Stroop (colour word) task, and immediate word recall and number sequence test. Vascular function was also assessed via Pulse Wave Velocity, Augmentation Index, blood pressure and height and weight.
Methods: Eight participants were recruited (aged 18-30) and received fresh sage tablets (Menoforce® 51g tablets) which of they were to take one daily for 14 days. Assessment of cognitive function involved the three cognitive tests that assessed different aspects of memory at study days 0, 1, 7 and 14. Height and weight were measured before cardiovascular parameters which were also measured on study days which included systolic and diastolic blood pressure, heart rate, pulse wave velocity and augmentation index. The results were then statistically analysed.
Results: Sage significantly reduced time taken to complete Stroop (colour word) test (p<0.05) with further effects seen on the number sequence test where the length of numbers remembered over time increases although not significantly. Decreases were seen in systolic blood pressure, diastolic blood pressure and pulse wave velocity. Trends in augmentation index and heart rate seem to be very similar as the both increase and decrease at the same points.
Conclusion: The findings of the study do support previous results that Salvia Officinalis can work significantly as a memory enhancer on processing memory long term, with further effects seen on working memory. Polyphenol content may be what contributes to a reduction in Pulse Wave Velocity, Augmentation Index, Blood Pressure and Heart Rate. There could be many mechanisms involved in the beneficial effects of sage, so further studies should be aimed at what constitutes in particular are causing the cognitive enhancing effects and the improvement in vascular function.
Key words: Sage, Cognitive function, Antioxidants, Pulse Wave Velocity, Blood Pressure||