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dc.rights.licenseOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.contributor.authorCollie, Daviden
dc.contributor.authorMurchison, John T.en
dc.contributor.authorWright, Steven H.en
dc.contributor.authorMcLean, Alecen
dc.contributor.authorHoward, Lynseyen
dc.contributor.authordel-Pozo, Jorgeen
dc.contributor.authorSmith, Sionaghen
dc.contributor.authorMcLachlan, Gerryen
dc.contributor.authorLawrence, Jessicaen
dc.contributor.authorKay, Elaineen
dc.contributor.authorSchwarz, Tobiasen
dc.contributor.authorParys, Magdalenaen
dc.date.accessioned2019-01-21T11:48:22Z
dc.date.available2019-01-21T11:48:22Z
dc.date.issued2018-09-06
dc.identifier.citationCollie, D., Murchison, J. T., Wright, S. H., McLean, A., Howard, L., del-Pozo, J., Smith, S., McLachlan, G., Lawrence, J., Kay, E., Schwarz, T. & Parys, M. (2018) Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model. Scientific Reports, 8, Article number: 13316.en
dc.identifier.issn2045-2322en
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/9177
dc.identifier.urihttps://doi.org/10.1038/s41598-018-31559-3
dc.descriptionItem originally deposited in University of Edinburgh, Edinburgh Research Explorer Repository at: https://www.research.ed.ac.uk/portal/en/publications/nebulisation-of-synthetic-lamellar-lipids-mitigates-radiationinduced-lung-injury-in-a-large-animal-model(ab917c99-7e7f-4fa1-8d1e-40511ca9abd3).htmlen
dc.description.abstractMethods to protect against radiation-induced lung injury (RILI) will facilitate the development of more effective radio-therapeutic protocols for lung cancer and may provide the means to protect the wider population in the event of a deliberate or accidental nuclear or radiological event. We hypothesised that supplementing lipid membranes through nebulization of synthetic lamellar lipids would mitigate RILI. Following pre-treatment with either nebulised lamellar lipids or saline, anaesthetised sheep were prescribed fractionated radiotherapy (30 Gray (Gy) total dose in five 6 Gy fractions at 3–4 days intervals) to a defined unilateral lung volume. Gross pathology in radio-exposed lung 37 days after the first radiation treatment was consistent between treatment groups and consisted of deep red congestion evident on the pleural surface and firmness on palpation. Consistent histopathological features in radio-exposed lung were subpleural, periarteriolar and peribronchial intra-alveolar oedema, alveolar fibrosis, interstitial pneumonia and type II pneumocyte hyperplasia. The synthetic lamellar lipids abrogated radiation-induced alveolar fibrosis and reduced alpha-smooth muscle actin (ASMA) expression in radio-exposed lung compared to saline treated sheep. Administration of synthetic lamellar lipids was also associated with an increased number of cells expressing dendritic cell-lysosomal associated membrane protein throughout the lung.en
dc.description.sponsorshipThis work was supported by Grant MRC/CIC3/025 awarded to D.C., J.L., J.M., G.M. & J.P. The authors wish to acknowledge the assistance of Dryden Animal Services in the conduct of this work, and the assistance of Dr Helen Brown in relation to experimental design and statistical analysis. The authors are grateful to Lamellar Biomedical Ltd., Strathclyde Business Park, Bellshill, Scotland, United Kingdom, for the supply of LAMELLASOME™ used in this research.en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.ispartofScientific Reportsen
dc.rights© The Author(s) 2018
dc.subjectExperimental Models of Diseaseen
dc.subjectLung Canceren
dc.titleNebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal modelen
dc.typeArticleen
dcterms.accessRightspublic
dcterms.dateAccepted2018-08-17
dc.description.volume8en
dc.description.ispublishedpub
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2018-09-06
refterms.dateFCA2018-09-06
refterms.dateFCD2019-01-21
refterms.depositExceptionpublishedGoldOAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorKay, Elaineen
dc.description.statuspub
dc.description.numberArticle no: 13316en
refterms.versionVoRen
refterms.dateDeposit2019-01-21


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