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dc.rights.licenseCreative Commons Attribution (CC BY) license
dc.contributor.authorAnderson, Graham W.
dc.contributor.authorKenyon, Christopher J.
dc.contributor.authorAl-Dujaili, Emad A. S.
dc.date.accessioned2019-02-27T01:38:58Z
dc.date.available2019-02-27T01:38:58Z
dc.date.issued2019-02-09
dc.date.submitted2019-01-14
dc.identifier.citationAnderson, G. W., Kenyon, C. J. & Al-Dujaili, E. A. S. (2019) Post-prandial changes in salivary glucocorticoids: Effects of dietary cholesterol and associations with bile acid excretion. Nutrients, 11(2):360.
dc.identifier.issn2072-6643
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/9397
dc.identifier.urihttps://doi.org/10.3390/nu11020360
dc.description.abstractMechanisms to explain post-prandial increases in circulating glucocorticoids are not well understood and may involve increased adrenal secretion and/or altered steroid metabolism. We have compared salivary levels of cortisol and cortisone levels in healthy male and female volunteers fed either a low or cholesterol-rich midday meal. Urinary levels of steroids, bile acids and markers of lipid peroxidation were also measured. Males and females showed expected circadian changes in salivary steroids and postprandial peaks within 1h of feeding. After a high-cholesterol meal, postprandial cortisol increases were higher in males whereas post-prandial cortisone levels were higher in females. Urinary cortisol but not cortisone levels were higher on the day when males and females ate a high-cholesterol meal. Urinary bile acid excretion and anti-oxidant markers of lipid peroxidation, thiobarbituric acid reactive substances (TBARS), and total phenol content were not affected by dietary cholesterol but tended to be higher in males. Cross-tabulation of correlation coefficients indicated positive associations between urinary markers of peroxidation, bile acids, and cortisol:cortisone ratios. We conclude that dietary cholesterol (a substrate for steroidogenesis) does not have an acute effect on adrenal glucocorticoid synthesis and that gender but not a high-cholesterol meal may influence the interconversion of cortisol and cortisone. Longer term studies of the effects of dietary cholesterol are needed to analyze the associations between bile acids, steroid metabolism, and secretion and lipid peroxidation.
dc.languageeng
dc.relation.ispartofNutrients
dc.rights© 2019 by the authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBile Acids
dc.subjectCholesterol
dc.subjectCortisol
dc.subjectDiet
dc.subjectGlucocorticoids
dc.titlePost-prandial changes in salivary glucocorticoids: Effects of dietary cholesterol and associations with bile acid excretion
dc.typearticle
dcterms.accessRightspublic
dcterms.dateAccepted2019-02-06
dc.date.updated2019-02-27T01:38:58Z
dc.description.volume11
dc.description.ispublishedpub
refterms.depositExceptionpublishedGoldOA
qmu.authorAnderson, Graham W.
qmu.authorAl-Dujaili, Emad A. S.
dc.description.statuspub
dc.description.number2


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Except where otherwise noted, this item's license is described as Creative Commons Attribution (CC BY) license