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dc.contributor.authorSakkas, G. K.
dc.contributor.authorSargeant, A. J.
dc.contributor.authorMercer, Tom
dc.contributor.authorBall, Derek
dc.contributor.authorTolfrey, K.
dc.contributor.authorNaif, P. F.
dc.date.accessioned2018-06-29T21:45:09Z
dc.date.available2018-06-29T21:45:09Z
dc.date.issued2003-10
dc.identifierER94
dc.identifier.citationSakkas, G., Sargeant, A., Mercer, T., Ball, D., Tolfrey, K. & Naif, P. (2003) Atrophy of non-locomotor muscle in patients with end-stage renal failure, Nephrology Dialysis Transplantation, vol. 18, , pp. 2074-2081,
dc.identifier.issn9310509
dc.identifier.urihttp://dx.doi.org/10.1093/ndt/gfg325
dc.identifier.urihttp://www.oxfordjournals.org/
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/94
dc.descriptionResearch publication emanating from an externally funded (Greek Government Scholarship) PhD study (Sakkas; Sargeant as Director of Studies and Mercer as Supervisor) and activities of Renal Rehabilitation research group led by Mercer and Naish.
dc.description.abstractBackground. All previous histological studies of skeletal muscles of patients with renal failure have used locomotor muscle biopsies. It is thus unclear to what degree the observed abnormalities are due to the uraemic state and how much is due to disuse. The present study was undertaken to attempt to investigate this question by examining a non-locomotor muscle (rectus abdominis) in patients with end-stage renal failure. Methods. Biopsies from rectus abdominis were obtained from 22 renal failure patients (RFPs) undergoing surgical Tenchkoff catheter implantation for peritoneal dialysis and 20 control subjects undergoing elective abdominal surgery. Histochemical staining of frozen sections and morphometric analysis was used to estimate the proportion of each fibre type, muscle fibre area and capillary density. Myosin heavy chain composition was examined by SDS-PAGE. Results. There were no differences in fibre type distribution between RFPs and controls. All RFPs showed fibre atrophy [mean cross-sectional area (CSA) 3300 1100 m2, compared to 4100 1100 m2 in controls (P < 0.05)]. All fibre types were smaller in mean CSA in RFPs than in controls (15, 26 and 28% for types I, IIa and IIx, respectively). These differences could not be accounted for by differences in age, gender or cardiovascular or diabetic comorbidity. Muscle fibre capillarization, expressed as capillaries per fibre or capillary contacts per fibre, was significantly less in RFPs. Conclusions. Since a non-locomotor muscle was examined, the effects of disuse as a cause of atrophy have been minimized. It is likely, therefore, that the decreased muscle fibre CSA and capillary density of RFPs compared to controls were due predominantly to uraemia itself.
dc.description.abstractPaper adds to the growing body of evidence that children can acquire phonological systems before they are able to master the phonetic skills needed to convey the contrasts in that system
dc.format.extent2074-2081
dc.publisherOxford University Press
dc.relation.ispartofNephrology Dialysis Transplantation
dc.subjectatrophy
dc.subjectnon-locomotor muscle
dc.subjectrenal failure
dc.titleAtrophy of non-locomotor muscle in patients with end-stage renal failure
dc.typearticle
dcterms.accessRightsrestricted
dc.description.facultysch_phy
dc.description.referencetextClyne N, Esbjornsson M, Jansson E, Jogestrand T, Lins LE, Pehrsson SK. Effect of renal failure on skeletal muscle. Nephron 1993; 63: 395-399[Medline] Kouidi E, Albani M, Natsis K et al. The effects of exercise training on muscle atrophy in haemodialysis patients. Nephrol Dial Transplant 1998; 13: 685-699[Abstract/Free Full Text] Ayus J, Frommer P, Young JB. Cardiac and circulatory abnormalities in chronic renal failure. Semin Nephrol 1981; 1: 112-123 Bradley JR, Anderson JR, Evans DB, Cowley AJ. Impaired nutritive skeletal muscle blood flow in patients with chronic renal failure. Clin Sci 1990; 79: 239-245[Medline] Diesel W, Knight B, Noakes TD et al. Morphologic features of the myopathy associated with chronic renal failure. Am J Kidney Dis 1993; 22: 677-684[ISI][Medline] Moore GE, Parsons DB, Stray-Gundersen J, Painter PL, Brinker KR, Mitchell JH. Uremic myopathy limits aerobic capacity in hemodialysis patients. Am J Kidney Dis 1993; 22: 277-287[ISI][Medline] Fahal HI, Bell GM, Bone JM, Edwards RHT. Physiological abnormalities of skeletal muscle in dialysis patients. Nephrol Dial Transplant 1997; 12: 119-127[Abstract/Free Full Text] Davenport A, King RFGJ, Ironside JW, Will EJ, Davison AM. The effect of treatment with recombinant erythropoietin on the histological appearance and glycogen content of skeletal muscle in patients with chronic renal failure treated with regular hospital dialysis. Nephron 1993; 64: 89-94[Medline] Bautista J, Gil-Necija E, Castilla I, Chinchon I, Rafel E. Dialysis myopathy. Acta Neuropathol 1983; 61: 71-75[Medline] Fernandes Do Prado LB, Fernandes Do Prado G, Oliviera ASB, Schmidt B, De Abreu Carvalhaes JT. Histochemical study of the skeletal muscle in children with chronic renal failure in dialysis treatment. Arq Neuropsiquatr 1998; 56: 381-387 Detsky AS, McLaughlin JR, Baker JP et al. What is subjective global assessment of nutritional status? J Parenter Enteral Nutr 1987; 11: 8-13[Abstract] Enia G, Sicuso C, Alati G, Zoccali C. Subjective global assessment of nutrition in dialysis patients. Nephrol Dial Transplant 1993; 8: 1094-1098[Abstract/Free Full Text] Gokal R, Nolph KD. Textbook of Peritoneal Dialysis. Kluwer Academic Publishers, Amsterdam, The Netherlands: 1994; 271-314 Brooke MH, Kaiser KK. Muscle fibre types: how many and what kind? Arch Neurol 1970; 23: 369-379[ISI][Medline] Andersen P. Capillary density in skeletal muscle of man. Acta Physiol Scand 1975; 95: 203-205[ISI][Medline] Talmadge RJ, Roy RR. Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms. J Appl Physiol 1993; 75: 2337-2340[Abstract/Free Full Text] Conjard A, Ferrier B, Martin M, Cailette A, Carrier H, Baverel G. Effect of chronic renal failure on enzymes of energy metabolism in individual human muscles fibres. J Am Soc Nephrol 1995; 6: 68-74[Abstract] Haggmark T, Thorstensson A. Fibres types in human abdominal muscles. Acta Physiol Scand 1979; 107: 319-325[ISI][Medline] Mitch WE, Goldberg AL. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 1996; 335: 1897-1905[Free Full Text] Reaich D, Channon SM, Scrimgeour CM, Daley SE, Wilkinson R, Goodship TH. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol 1993; 265: E230-E235[Medline] Stein A, Moorhouse J, Iles-Smith H et al. Role of improvement in acid-base status and nutrition in CAPD patients. Kidney Int 1997; 52: 1089-1095[ISI][Medline] Brady JP, Hasbargen JA. Correction of metabolic acidosis and its effects on albumin in chronic hemodialysis patients. Am J Kidney Dis 1998; 31: 35-40[Medline] Brooke MH, Engel WK. The histologic diagnosis of neuromuscular diseases: a review of 79 biopsies. Arch Phys Med Rehab 1966; 47: 99-121[Medline] Guthrie M, Cardenas D, Eschbach JW, Haley NR, Robertson HT, Evans RW. Effect of erythropoietin on strength and functional status of patients on hemodialysis. Clin Nephrol 1993; 39: 97-102[Medline] Sargeant AJ, Davies CT, Edwards RH, Maunder C, Young A. Functional and structural changes after disuse of human muscle. Clin Sci Mol Med 1977; 52: 337-342[ISI][Medline] Bloomfield SA. Changes in musculoskeletal structure and function with prolonged bed rest. Med Sci Sports Exerc 1997; 29: 197-206 Amann K, Breitbach M, Ritz E, Mall G. Myocyte/capillary mismatch in the heart of uremic patients. Am J Soc Nephrol 1998; 9: 1018-1022[Abstract]
dc.description.volume18
dc.identifier.doihttp://10.1093/ndt/gfg325
dc.description.ispublishedpub
dc.description.eprintid94
rioxxterms.typearticle
qmu.authorMercer, Tom
dc.description.statuspub
dc.description.number10


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