A critical review of the current theories relating to the development of Diabetic Charcot Neuroarthropathy & extended research proposal
Diabetic Charcot Neuroarthropathy is an elusive disease that’s true pathophysiology is unknown. This disease is difficult to recognise in the acute stage and can lead to significant deformity of the foot and in the worse of cases amputation. In this dissertation there will be a critical review of current research studies and from this an extended research study will be proposed. Objective A critical review of research studies looking at the Pathophysiology and associated risk factors in the development of Diabetic Charcot Neuroarthropathy. From this the author will propose an extended research proposal using information for the critical review with the aim to further the study into the pathophysiology and/or associated risk factors in the development of Diabetic Charcot Neuroarthropathy. Data sources Electronic database searches on EBSCO CINAHL, CINAHL plus, medline, Science direct, Scopus, science citation index, Ovid Embase and Wiley CCTR, using key search words. Results A total of 19 research papers were selected that were of an acceptable quality and met search criteria and included the inflammatory, genetic and neurovascular theories and associated risk factors BMI and Hyperglycaemia. Conclusion The Critical review of the key research studies associated with the risk factors in the development of and pathophysiology of DCN has demonstrated that many of the studies are of a poor design, are often low in subject numbers, lack relevant control groups and have not targeted those in the acute phase of the disease process. This critical literature review has highlighted a need for larger, quality study’s looking at those newly diagnosed with DCN to see if any statistical significance can be found in the most commonly describe risk factors such as BMI and glycaemic control.