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dc.contributor.authorBlackwood, Honor A.en
dc.contributor.authorHall, Charlie C.en
dc.contributor.authorBalstad, Trude R.en
dc.contributor.authorSolheim, Tora S.en
dc.contributor.authorFallon, Marie T.en
dc.contributor.authorHaraldsdottir, Ernaen
dc.contributor.authorLaird, Barry J.en
dc.date.accessioned2019-08-26T15:18:15Z
dc.date.available2019-08-26T15:18:15Z
dc.date.issued2019-07-29
dc.identifier.citationBlackwood, H. A., Hall, C. C., Balstad, T. R., Solheim, T. S., Fallon, M. T., Haraldsdottir, E. & Laird, B. J. (2020) A systematic review examining nutrition support interventions in patients with incurable cancer. Supportive Care in Cancer, 28, pp. 1877-1889.en
dc.identifier.issn1433-7339en
dc.identifier.issn0941-4355
dc.identifier.urihttps://eresearch.qmu.ac.uk/handle/20.500.12289/9943
dc.identifier.urihttps://doi.org/10.1007/s00520-019-04999-4
dc.description.abstractPurpose: Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer: however, little is known about the optimal type of nutritional intervention. The aim of this review was to assess the current evidence for nutrition support in patients with incurable cancer. Methods: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. EMBASE, Medline and CINAHL were searched from 1990-2018. Evidence was appraised using a modified risk of bias table, based on guidance from the Cochrane Handbook for Systematic Reviews of Interventions. Results: Sixty studies were assessed of which twelve met the eligibility criteria. Eleven studies examined body composition, with six studies reporting improvements in weight. Six studies examined nutritional status with three studies reporting an improvement. Nine studies examined nutritional intake with six showing improvements including significant improvements in dietary and protein intake. Ten studies examined quality of life, with six studies reporting improvements following intervention. The most common nutritional interventions examined were nutrition counselling and dietary supplementation. Conclusions: There is moderate quality evidence to support the need for increased attention to nutrition support in patients with incurable cancer; however, despite some statistically significant results being reported the clinical effects of them were small. Key questions remain as to the optimal timing for these interventions to be implemented (e.g. cachexia stage, illness stage, timing with anticancer therapy) and the most appropriate endpoint measures.en
dc.description.sponsorshipThis work was financially supported by the Nancie Massey Charitable Trust, Miss M B Reekie’s Charitable Trust and the P F Charitable Trust.
dc.description.urihttps://doi.org/10.1007/s00520-019-04999-4en
dc.format.extent1877-1889
dc.language.isoenen
dc.publisherSpringer Berlin Heidelbergen
dc.relation.ispartofSupportive Care in Canceren
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Supportive Care in Cancer. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00520-019-04999-4.
dc.subjectWeighten
dc.subjectSupplementsen
dc.subjectCanceren
dc.subjectNutritional Interventionsen
dc.subjectCachexiaen
dc.subjectNutrition Supporten
dc.titleA systematic review examining nutrition support interventions in patients with incurable canceren
dc.typeArticleen
dcterms.accessRightspublic
dcterms.dateAccepted2019-07-16
dc.description.volume28
dc.description.ispublishedpub
rioxxterms.typeJournal Article/Reviewen
rioxxterms.publicationdate2019-07-19
refterms.dateEmbargoEnd2020-07-19
refterms.dateFCD2019-08-26
refterms.depositExceptionNAen
refterms.accessExceptionNAen
refterms.technicalExceptionNAen
refterms.panelUnspecifieden
qmu.authorHaraldsdottir, Ernaen
qmu.centreCentre for Person-centred Practise Researchen
dc.description.statuspub
refterms.versionAMen
refterms.dateDeposit2019-08-26


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