CC BY 4.0 DEED Attribution 4.0 InternationalYoung, Hannah M.Castle, Ellen M.Briggs, JulietWalklin, ChristyBillany, Roseanne E.Asgari, ElhamBhandari, SunilBishop, NicoletteBramham, KateBurton, James O.Campbell, JackieChilcot, JosephCooper, NicolaDeelchand, VashistGraham-Brown, Matthew P. M.Haggis, LyndaHamilton, AlexanderJesky, MarkKalra, Philip A.Koufaki, PelagiaMacdonald, JamieMcCafferty, KieranNixon, Andrew C.Noble, HelenSaynor, Zoe L.Taal, Maarten W.Tollitt, JamesWheeler, David C.Wilkinson, Thomas J.Greenwood, Sharlene A.2024-01-152024-01-152024-01-062023-09-15Young, H.M.L., Castle, E.M., Briggs, J., Walklin, C., Billany, R.E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J.O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M.P.M., Haggis, L., Hamilton, A., Jesky, M., Kalra, P.A., Koufaki, P., Macdonald, J., McCafferty, K., Nixon, A.C., Noble, H., Saynor, Z.L., Taal, M.W., Tollitt, J., Wheeler, D.C., Wilkinson, T.J. and Greenwood, S.A. (2024) ‘The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney beam) for people with chronic kidney disease’, Scientific Reports, 14(1), p. 700. Available at: https://doi.org/10.1038/s41598-023-50507-4.https://eresearch.qmu.ac.uk/handle/20.500.12289/13642https://doi.org/10.1038/s41598-023-50507-4From Springer Nature via Jisc Publications RouterHistory: received 2023-09-15, registration 2023-12-20, accepted 2023-12-20, epub 2024-01-06, online 2024-01-06, collection 2024-12Acknowledgements: The authors acknowledge the work of the various research teams at each site and thank all the participants involved in this research. This research was prospectively registered NCT04872933.Publication status: PublishedPelagia Koufaki - ORCID: 0000-0002-1406-3729 https://orcid.org/0000-0002-1406-3729This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity and emotional well-being self-management digital health intervention (DHI) for people with chronic kidney disease (CKD), which offers live and on-demand physical activity sessions, educational blogs and videos, and peer support. In this mixed-methods, multicentre randomised waitlist-controlled internal pilot, adults with established CKD were recruited from five NHS hospitals and randomised 1:1 to Kidney BEAM or waitlist control. Feasibility outcomes were based upon a priori progression criteria. Acceptability was primarily explored via individual semi-structured interviews (n = 15). Of 763 individuals screened, n = 519 (68%, 95% CI 65 to 71%) were eligible. Of those eligible, n = 303 (58%, 95% CI 54–63%) did not respond to an invitation to participate by the end of the pilot period. Of the 216 responders, 50 (23%, 95% CI 18–29%) consented. Of the 42 randomised, n = 22 (10 (45%) male; 49 ± 16 years; 14 (64%) White British) were allocated to Kidney BEAM and n = 20 (12 (55%) male; 56 ± 11 years; 15 (68%) White British) to the waitlist control group. Overall, n = 15 (30%, 95% CI 18–45%) withdrew during the pilot phase. Participants completed a median of 14 (IQR 5–21) sessions. At baseline, 90–100% of outcome data (patient reported outcome measures and a remotely conducted physical function test) were completed and 62–83% completed at 12 weeks follow-up. Interview data revealed that remote trial procedures were acceptable. Participants’ reported that Kidney BEAM increased their opportunity and motivation to be physically active, however, lack of time remained an ongoing barrier to engagement with the DHI. An randomised controlled trial of Kidney BEAM is feasible and acceptable, with adaptations to increase recruitment, retention and engagement. Trial registration NCT04872933. Date of first registration 05/05/2021.Licence for this article: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/article2024-01-06