Zaremba, SuzanneGow, Iain F.Drummond, SandraMcCluskey, Jane T.Steinert, Robert E.2018-07-272018-07-272018-06-18Zaremba, S., Gow, I. F., Drummond, S., McCluskey, J. T. & Steinert, Robert E. (2018) Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects. Appetite, 128, pp. 197-204.1095-8304https://doi.org/10.1016/j.appet.2018.06.019https://eresearch.qmu.ac.uk/handle/20.500.12289/5412** From PubMed via Jisc Publications Router. ** History: received 23-03-2018; revised 12-06-2018; accepted 15-06-2018.There is evidence that oat β-glucan lowers appetite and ad libitum eating; however, not all studies are consistent, and the underpinning mechanisms are not entirely understood. We investigated the effects of 4 g high molecular weight (MW) oat β-glucan on ad libitum eating, subjective appetite, glycemia, insulinemia and plasma GLP-1 responses in 33 normal-weight subjects (22 female/11 male, mean age (y): 26.9 ± 1.0, BMI (kg/m ): 23.5 ± 0.4). The study followed a randomised double-blind, cross-over design with subjects fed two test breakfasts with and without oat β-glucan followed by an ad libitum test meal on two different days. Blood samples and ratings for subjective appetite were collected postprandially at regular time intervals. Oat β-glucan increased feelings of fullness (p = 0.048) and satiety (p = 0.034), but did not affect energy and amount eaten at the ad libitum test meal. There was a treatment by time interaction for plasma GLP-1, plasma insulin and blood glucose. GLP-1 was significantly reduced at 90 min (p = 0.021), blood glucose at 30 min (p = 0.008) and plasma insulin at 30 and 60 min (p = 0.002 and 0.017, respectively) following the oat β-glucan breakfast when compared with the control breakfast. Four grams of high MW oat β-glucan lowers appetite but not ad libitum eating and beneficially modulates postprandial glycaemia, it does however, not increase plasma GLP-1 secretion. [Abstract copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.]197-204© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Energy IntakeGLP-1GlucoseInsulinOat β-glucanSatietyarticlehttps://dx.doi.org/10.1016/j.appet.2018.06.019